Y 染色体进化：对 Y 染色体退化过程的新认识。
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration.
机构信息
Department of Integrative Biology, Center for Theoretical Evolutionary Genomics, University of California Berkeley, Berkeley, California 94720, USA.
出版信息
Nat Rev Genet. 2013 Feb;14(2):113-24. doi: 10.1038/nrg3366.
Abstract
The human Y chromosome is intriguing not only because it harbours the master-switch gene that determines gender but also because of its unusual evolutionary history. The Y chromosome evolved from an autosome, and its evolution has been characterized by massive gene decay. Recent whole-genome and transcriptome analyses of Y chromosomes in humans and other primates, in Drosophila species and in plants have shed light on the current gene content of the Y chromosome, its origins and its long-term fate. Furthermore, comparative analysis of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the evolutionary destiny of the Y chromosome.
摘要
人类的 Y 染色体不仅因其包含决定性别这一主开关的基因而令人着迷，还因其不同寻常的进化史而令人着迷。Y 染色体由一条常染色体进化而来，其进化的特点是大量基因缺失。最近对人类和其他灵长类动物、果蝇物种和植物的 Y 染色体的全基因组和转录组分析，揭示了 Y 染色体的当前基因组成、起源及其长期命运。此外，对新旧 Y 染色体的比较分析进一步深入了解了导致 Y 染色体退化的进化和分子力量，以及 Y 染色体的进化命运。
相似文献
1
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration.Y 染色体进化：对 Y 染色体退化过程的新认识。
Nat Rev Genet. 2013 Feb;14(2):113-24. doi: 10.1038/nrg3366.
2
[The evolution of human Y chromosome].[人类Y染色体的进化]
Yi Chuan. 2014 Sep;36(9):849-56. doi: 10.3724/SP.J.1005.2014.0849.
3
Multicopy gene family evolution on primate Y chromosomes.灵长类Y染色体上的多拷贝基因家族进化
BMC Genomics. 2016 Feb 29;17:157. doi: 10.1186/s12864-015-2187-8.
4
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.人类和恒河猴的 Y 染色体经历了快速基因丢失，随后出现严格的进化保守性。
Nature. 2012 Feb 22;483(7387):82-6. doi: 10.1038/nature10843.
5
Inter- and intraspecies phylogenetic analyses reveal extensive X-Y gene conversion in the evolution of gametologous sequences of human sex chromosomes.种间和种内系统发育分析揭示了人类性染色体配子同源序列进化过程中广泛的X-Y基因转换。
Mol Biol Evol. 2014 Aug;31(8):2108-23. doi: 10.1093/molbev/msu155. Epub 2014 May 8.
6
Evolutionary breakpoint analysis on Y chromosomes of higher primates provides insight into human Y evolution.高等灵长类动物Y染色体的进化断点分析为人类Y染色体进化提供了见解。
Cytogenet Genome Res. 2005;108(1-3):204-10. doi: 10.1159/000080817.
7
Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content.黑猩猩和人类的 Y 染色体在结构和基因组成上有显著差异。
Nature. 2010 Jan 28;463(7280):536-9. doi: 10.1038/nature08700. Epub 2010 Jan 13.
8
Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee.通过黑猩猩的比较测序揭示人类进化过程中Y染色体连锁基因的保守性
Nature. 2005 Sep 1;437(7055):100-3. doi: 10.1038/nature04101.
9
[Evolutive divergence between human and chimpanzee Y chromosomes].[人类与黑猩猩Y染色体之间的进化差异]
Med Sci (Paris). 2010 May;26(5):464-5. doi: 10.1051/medsci/2010265464.
10
Should Y stay or should Y go: the evolution of non-recombining sex chromosomes.Y 留还是 Y 走：非重组性染色体的演化。
Bioessays. 2012 Nov;34(11):938-42. doi: 10.1002/bies.201200064. Epub 2012 Sep 5.
引用本文的文献
1
Genomic evidence for males of exceptional reproductive output (ERO) in apes and humans.猿类和人类中具有超常繁殖力（ERO）的雄性的基因组证据。
Natl Sci Rev. 2025 Jun 28;12(9):nwaf257. doi: 10.1093/nsr/nwaf257. eCollection 2025 Sep.
2
Evidence against the role of toll-like receptors 7 and 8 in sex selection in mice, cattle, and humans.反对Toll样受体7和8在小鼠、牛及人类性别选择中起作用的证据。
iScience. 2025 Jul 18;28(9):113164. doi: 10.1016/j.isci.2025.113164. eCollection 2025 Sep 19.
3
Genomic origins and evolution of neo-sex chromosomes in Pacific Island birds.太平洋岛屿鸟类新性染色体的基因组起源与演化
Proc Natl Acad Sci U S A. 2025 Aug 5;122(31):e2503746122. doi: 10.1073/pnas.2503746122. Epub 2025 Jul 28.
4
An Extension of Muller's Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.穆勒庇护假说对性染色体基因含量进化的扩展
Mol Biol Evol. 2025 Jul 30;42(8). doi: 10.1093/molbev/msaf177.
5
Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes.具有同型性染色体的棘胸蛙中性别连锁转录本的性别偏向性表达。
BMC Genomics. 2025 Jul 5;26(1):636. doi: 10.1186/s12864-025-11846-w.
6
Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation.性连锁染色体倒位的渐渗动态塑造了马拉维丽鱼科鱼类的辐射演化。
Science. 2025 Jun 12;388(6752):eadr9961. doi: 10.1126/science.adr9961.
7
A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback.抗缪勒氏管激素的Y连锁重复是三刺鱼的性别决定基因。
bioRxiv. 2025 Apr 29:2025.04.28.650899. doi: 10.1101/2025.04.28.650899.
8
Repeated loss of function at HD mating-type genes and of recombination in anther-smut fungi.花药黑粉菌中HD交配型基因的功能反复丧失及重组现象
Nat Commun. 2025 May 28;16(1):4962. doi: 10.1038/s41467-025-60222-5.
9
Assembly and analysis of Sinipercidae fish sex chromosomes reveals that a supergene drives sex chromosome origin and turnover.鳜科鱼类性染色体的组装与分析表明，一个超级基因驱动了性染色体的起源和更替。
Adv Biotechnol (Singap). 2025 May 28;3(2):17. doi: 10.1007/s44307-025-00068-6.
10
Variable organization of repeats and hidden diversity of XY sex chromosomes in Pentatomidae true Bugs (Hemiptera) revealed through comparative genomic hybridization.通过比较基因组杂交揭示的蝽科（半翅目）真蝽中重复序列的可变组织和XY性染色体的隐藏多样性
Chromosoma. 2025 May 26;134(1):4. doi: 10.1007/s00412-025-00831-7.
本文引用的文献
1
SEX CHROMOSOMES AND THE EVOLUTION OF SEXUAL DIMORPHISM.性染色体与两性异形的进化
Evolution. 1984 Jul;38(4):735-742. doi: 10.1111/j.1558-5646.1984.tb00346.x.
2
Sex-biased transcriptome evolution in Drosophila.果蝇的性别偏向性转录组进化。
Genome Biol Evol. 2012;4(11):1189-200. doi: 10.1093/gbe/evs093.
3
Sequencing papaya X and Yh chromosomes reveals molecular basis of incipient sex chromosome evolution.测序番木瓜 X 和 Yh 染色体揭示了初生性染色体进化的分子基础。
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13710-5. doi: 10.1073/pnas.1207833109. Epub 2012 Aug 6.
4
Sex-specific adaptation drives early sex chromosome evolution in Drosophila.性别特异性适应驱动果蝇早期性染色体进化。
Science. 2012 Jul 20;337(6092):341-5. doi: 10.1126/science.1225385.
5
Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila.Y 染色体介导核糖体 DNA 沉默，并调节果蝇中的染色质状态。
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9941-6. doi: 10.1073/pnas.1207367109. Epub 2012 Jun 4.
6
Genomics and genetics of human and primate y chromosomes.人类和灵长类动物 Y 染色体的基因组学和遗传学。
Annu Rev Genomics Hum Genet. 2012;13:83-108. doi: 10.1146/annurev-genom-090711-163855. Epub 2012 Apr 5.
7
Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.解析白眼果蝇的基因组草图揭示新性染色体和 B 染色体的进化。
BMC Genomics. 2012 Mar 22;13:109. doi: 10.1186/1471-2164-13-109.
8
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.人类和恒河猴的 Y 染色体经历了快速基因丢失，随后出现严格的进化保守性。
Nature. 2012 Feb 22;483(7387):82-6. doi: 10.1038/nature10843.
9
Chromosome-wide gene silencing initiates Y degeneration in Drosophila.染色体范围的基因沉默引发果蝇 Y 染色体退化。
Curr Biol. 2012 Mar 20;22(6):522-5. doi: 10.1016/j.cub.2012.01.057. Epub 2012 Feb 23.
10
Sex chromosomes evolved from independent ancestral linkage groups in winged insects.性染色体是从有翅昆虫独立的祖先连锁群进化而来的。
Mol Biol Evol. 2012 Jun;29(6):1645-53. doi: 10.1093/molbev/mss010. Epub 2012 Jan 16.
Zotero 插件