注意缺陷多动障碍与糖尿病的关联：一项基于人群的研究。
Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study.
机构信息
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
出版信息
Pediatr Res. 2013 Apr;73(4 Pt 1):492-6. doi: 10.1038/pr.2013.5. Epub 2013 Jan 17.
BACKGROUND
Cognitive impairment has been documented in adult diabetes but is unclear in pediatric diabetes. No study had been conducted to explore the relationship between attention-deficit/hyperactivity disorder (ADHD) and diabetes. Using a population-based data set, we aimed to examine the association between ADHD and a prior diagnosis of diabetes mellitus (DM) in Taiwan.
METHODS
A total of 4,302 patients with ADHD were selected as cases and 21,510 randomly selected subjects as controls. We used conditional logistic regression to calculate the odds ratio (OR) for having previously received a diagnosis of DM between subjects with and without ADHD.
RESULTS
In this study, 116 of the 25,812 sampled subjects (0.5%) had received a diagnosis of DM prior to their index date. Subjects with ADHD had a higher proportion of prior DM diagnoses than controls (0.9% vs. 0.4%, P < 0.001). After adjusting for age, sex, index year, geographic location, and obesity, ADHD was significantly associated with a prior diagnosis of type 2 DM (OR = 2.75, 95% confidence interval (CI) = 1.82-4.16). However, no significant association was observed between ADHD and type 1 DM.
CONCLUSION
The findings suggest that ADHD was associated with a previous diagnosis of type 2 DM.
背景
成人糖尿病患者的认知障碍已得到证实，但在儿科糖尿病患者中尚不清楚。没有研究探讨注意力缺陷多动障碍（ADHD）与糖尿病之间的关系。本研究使用基于人群的数据集，旨在探讨台湾 ADHD 患者与糖尿病前期诊断之间的关系。
方法
共选择 4302 例 ADHD 患者作为病例，21510 例随机选择的患者作为对照。采用条件逻辑回归计算 ADHD 患者与无 ADHD 患者之间在指数日期之前诊断为糖尿病的优势比（OR）。
结果
本研究中，25812 名抽样患者中有 116 名（0.5%）在指数日期之前被诊断为糖尿病。与对照组相比，ADHD 患者的既往糖尿病诊断比例更高（0.9% vs. 0.4%，P < 0.001）。在校正年龄、性别、指数年份、地理位置和肥胖后，ADHD 与 2 型糖尿病的既往诊断显著相关（OR = 2.75，95%置信区间[CI] = 1.82-4.16）。然而，ADHD 与 1 型糖尿病之间没有显著关联。
结论
这些发现表明 ADHD 与 2 型糖尿病的前期诊断有关。
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