Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
J Gen Virol. 2013 Feb;94(Pt 2):293-297. doi: 10.1099/vir.0.042473-0.
Epidemics of H3N2 canine influenza virus (CIV) among dogs in South Korea and southern China have raised concern over the potential for zoonotic transmission of these viruses. Here, we analysed the pathogenesis and transmissibility of H3N2 CIV in ferret. H3N2 CIV replicated efficiently in the respiratory system of inoculated ferrets and caused acute necrotizing bronchioalveolitis and non-suppurative encephalitis. Transmission of H3N2 CIV was detected in three of six ferrets co-housed with inoculated ferrets, but no viruses were detected in second-contact ferrets. These findings show that H3N2 CIV has the capacity to replicate in and transmit partially among co-housed ferrets and underscore the need for continued public health surveillance.
韩国和中国南方的 H3N2 犬流感病毒（CIV）在犬群中的流行引起了人们对这些病毒可能在动物与人之间传播的担忧。在这里，我们分析了 H3N2 CIV 在雪貂中的发病机制和传染性。H3N2 CIV 在接种雪貂的呼吸系统中高效复制，导致急性坏死性细支气管炎和非化脓性脑炎。在与接种雪貂共同饲养的 6 只雪貂中检测到了 3 只传播了 H3N2 CIV，但在二次接触的雪貂中未检测到病毒。这些发现表明，H3N2 CIV 有能力在共同饲养的雪貂中复制并部分传播，并强调需要持续进行公共卫生监测。
