Terada Tadashi
Department of Pathology, Shizuoka City Shimizu Hospital Shizuoka, Japan.
Int J Clin Exp Pathol. 2013;6(2):191-8. Epub 2013 Jan 15.
The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions (23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, the number and frequency (percentages) were as follows: 263 chronic esophagitis (28.9%), 98 heterotopic gastric mucosa (10.8%), 3 heterotopic colonic mucosa (0.3%), 71 glycogenic acanthosis (7.8%), 68 candidiasis (7.5%), 35 benign ulcer (3.8%), 41 squamous papilloma (4.5%), 4 granular cell tumor (0.4%), 1 tubular adenoma (0.1%), 2 cytomegalovirus esophagitis (0.2%), 3 leiomyoma (0.3%), 17 basal cell hyperplasia (1.9%), and 37 Barrett's epithelium (4%). In malignant lesions, the number and frequency (percentages) were as follows: 53 mild dysplasia (5.8%), 29 moderate dysplasia (3.2%), 31 severe dysplasia (3.4%), 13 carcinoma in situ (1.4%), 68 squamous cell carcinoma (7.5%), 7 primary adenocarcinoma (0.8%), 1 primary signet ring cell carcinoma (0.1%), 4 primary small cell carcinoma (0.4%), 2 primary amelanotic malignant melanoma (0.2%), 1 primary undifferentiated sarcoma (0.1%), 7 gastric cancer invasion (0.8%), and 1 primary adenoid cystic carcinoma (0.1%). In this article, the clinicopathologic features of these esophageal lesions were described.
作者回顾了我院病理实验室过去15年连续910例食管活检病例。其中693例为正常黏膜和良性病变（76.2%），217例为恶性病变（23.8%）。50例活检（5.5%）食管未见明显改变。良性病变的数量及频率（百分比）如下：慢性食管炎263例（28.9%），异位胃黏膜98例（10.8%），异位结肠黏膜3例（0.3%），糖原棘皮症71例（7.8%），念珠菌病68例（7.5%），良性溃疡35例（3.8%），鳞状乳头状瘤41例（4.5%），颗粒细胞瘤4例（0.4%），管状腺瘤1例（0.1%），巨细胞病毒性食管炎2例（0.2%），平滑肌瘤3例（0.3%），基底细胞增生17例（1.9%），巴雷特食管上皮37例（4%）。恶性病变的数量及频率（百分比）如下：轻度不典型增生53例（5.8%），中度不典型增生29例（3.2%），重度不典型增生31例（3.4%），原位癌13例（1.4%），鳞状细胞癌68例（7.5%），原发性腺癌7例（0.8%），原发性印戒细胞癌1例（0.1%），原发性小细胞癌4例（0.4%），原发性无色素性恶性黑色素瘤2例（0.2%），原发性未分化肉瘤1例（0.1%），胃癌侵犯7例（0.8%），原发性腺样囊性癌1例（0.1%）。本文描述了这些食管病变的临床病理特征。
