Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
Biochem Pharmacol. 2012 Nov 15;84(10):1340-50. doi: 10.1016/j.bcp.2012.08.004.
Acute inflammation, the primary response to harmful infection and injury, can be successfully completed through effective resolution and tissue repair. Resolution of inflammation requires the elimination of key inflammatory cells and the downregulation of pro-inflammatory mediators in the inflamed sites. This coordinated process is actively regulated by biochemical mediators which possess anti-inflammatory and/or pro-resolving effects. Resolvins, endogenous lipid mediators generated from omega-3 fatty acids, have emerged as a novel class of potent molecules that counteract excessive inflammatory responses and stimulate pro-resolving mechanisms; regulating the trafficking of leukocytes and stimulating non-phlogistic phagocytosis of apoptotic neutrophils by macrophages.The disruption of these anti-inflammatory and pro-resolving mechanisms can not only cause the initiation of unnecessary inflammation, but also lead to the persistence of inflammation which contributes to the pathogenesis and progression of chronic inflammatory diseases. Since inflammation can have the beneficial effect on host defense, the timely resolution of inflammation is better to avoid chronic inflammatory situation, rather than merely blocking inflammation at the beginning. In this regards, understanding of the mechanism underlying resolution of inflammation provides a novel therapeutic approach to prevent and treat chronic inflammatory disorders. This review will address therapeutic potential of resolvins for the successful management of inflammatory ailments.
急性炎症是对有害感染和损伤的主要反应，可以通过有效的解决和组织修复来成功完成。炎症的解决需要消除关键的炎症细胞，并下调炎症部位的促炎介质。这个协调的过程是由具有抗炎和/或促解决作用的生化介质积极调节的。内源性脂质介质，来源于ω-3 脂肪酸，作为一种新的有效分子出现，可以对抗过度的炎症反应并刺激促解决机制；调节白细胞的迁移，并刺激巨噬细胞对凋亡中性粒细胞的非炎症性吞噬作用。这些抗炎和促解决机制的破坏不仅会导致不必要的炎症的开始，而且还会导致炎症的持续存在，从而导致慢性炎症性疾病的发病和进展。由于炎症对宿主防御具有有益的影响，因此及时解决炎症以避免慢性炎症情况更好，而不仅仅是在一开始就阻止炎症。在这方面，对炎症解决机制的理解为预防和治疗慢性炎症性疾病提供了一种新的治疗方法。这篇综述将探讨解决素在成功治疗炎症性疾病方面的治疗潜力。
