Astley S J, Little R E
Department of Pediatrics, University of Washington, Seattle 98195.
Neurotoxicol Teratol. 1990 Mar-Apr;12(2):161-8. doi: 10.1016/0892-0362(90)90129-z.
Prenatal marijuana exposure is associated with adverse perinatal effects. Very little is known about the effect of postnatal marijuana exposure on infant development. Postnatal exposure can result from maternal use of marijuana during lactation. Delta-9-tetrahydrocannabinol (THC) transfers and concentrates in the mother's milk and is absorbed and metabolized by the nursing infant. The present study investigated the relationship between infant exposure to marijuana via the mother's milk and infant motor and mental development at one year of age. One hundred and thirty-six breast-fed infants were assessed at one year of age for motor and mental development. Sixty-eight infants were exposed to marijuana via the mother's milk. An additional 68 infants were matched to the marijuana-exposed infants on pre- and postpartum maternal alcohol and tobacco use. Marijuana exposure via the mother's milk during the first month postpartum appeared to be associated with a decrease in infant motor development at one year of age.
产前接触大麻与围产期不良影响有关。关于产后接触大麻对婴儿发育的影响，人们了解甚少。产后接触可能源于母亲在哺乳期使用大麻。δ-9-四氢大麻酚（THC）会转移并浓缩在母乳中，被哺乳婴儿吸收并代谢。本研究调查了婴儿通过母乳接触大麻与一岁时婴儿运动和智力发育之间的关系。136名母乳喂养的婴儿在一岁时接受了运动和智力发育评估。68名婴儿通过母乳接触了大麻。另外68名婴儿在产前和产后母亲饮酒和吸烟情况方面与接触大麻的婴儿相匹配。产后第一个月通过母乳接触大麻似乎与一岁时婴儿运动发育下降有关。
