• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Amphiregulin 通过表皮生长因子受体增强调节性 T 细胞的抑制功能。

Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.

机构信息

Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, University of Utrecht, 3584 CL Utrecht, The Netherlands.

出版信息

Immunity. 2013 Feb 21;38(2):275-84. doi: 10.1016/j.immuni.2012.09.023. Epub 2013 Jan 17.

DOI:10.1016/j.immuni.2012.09.023
PMID:23333074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3582723/
Abstract

Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here we showed that Foxp3(+) regulatory T (Treg) cells express EGFR under inflammatory conditions. Stimulation with the EGF-like growth factor Amphiregulin (AREG) markedly enhanced Treg cell function in vitro, and in a colitis and tumor vaccination model we showed that AREG was critical for efficient Treg cell function in vivo. In addition, mast cell-derived AREG fully restored optimal Treg cell function. These findings reveal EGFR as a component in the regulation of local immune responses and establish a link between mast cells and Treg cells. Targeting of this immune regulatory mechanism may contribute to the therapeutic successes of EGFR-targeting treatments in cancer patients.

摘要

表皮生长因子受体 (EGFR) 已知在组织发育和稳态以及癌症的发病机制中起着关键作用。在这里，我们表明 Foxp3(+)调节性 T (Treg) 细胞在炎症条件下表达 EGFR。用 EGF 样生长因子 Amphiregulin (AREG) 刺激显着增强了 Treg 细胞在体外的功能，并且在结肠炎和肿瘤疫苗模型中，我们表明 AREG 对于 Treg 细胞在体内的有效功能至关重要。此外，肥大细胞衍生的 AREG 完全恢复了最佳的 Treg 细胞功能。这些发现揭示了 EGFR 是局部免疫反应调节的一个组成部分，并建立了肥大细胞和 Treg 细胞之间的联系。针对这种免疫调节机制可能有助于 EGFR 靶向治疗在癌症患者中的治疗成功。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/1a04400d0f54/nihms432886f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/a7087be40e3a/nihms432886f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/97b582ae0921/nihms432886f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/16f8fce15238/nihms432886f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/a6602ac9cacb/nihms432886f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/bac8e8906aef/nihms432886f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/1a04400d0f54/nihms432886f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/a7087be40e3a/nihms432886f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/97b582ae0921/nihms432886f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/16f8fce15238/nihms432886f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/a6602ac9cacb/nihms432886f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/bac8e8906aef/nihms432886f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a624/3582723/1a04400d0f54/nihms432886f6.jpg

相似文献

1
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Amphiregulin 通过表皮生长因子受体增强调节性 T 细胞的抑制功能。
Immunity. 2013 Feb 21;38(2):275-84. doi: 10.1016/j.immuni.2012.09.023. Epub 2013 Jan 17.
2
Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis.双调蛋白通过表皮生长因子受体/糖原合成酶激酶-3β/叉头框蛋白3轴赋予调节性T细胞抑制功能和肿瘤侵袭能力。
J Biol Chem. 2016 Sep 30;291(40):21085-21095. doi: 10.1074/jbc.M116.717892. Epub 2016 Jul 18.
3
Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression.嗜碱性粒细胞衍生的双调蛋白对于 UVB 照射诱导的免疫抑制是必需的。
J Invest Dermatol. 2015 Jan;135(1):222-228. doi: 10.1038/jid.2014.329. Epub 2014 Jul 4.
4
Membrane-bound Dickkopf-1 in Foxp3 regulatory T cells suppresses T-cell-mediated autoimmune colitis.Foxp3调节性T细胞中的膜结合型Dickkopf-1抑制T细胞介导的自身免疫性结肠炎。
Immunology. 2017 Oct;152(2):265-275. doi: 10.1111/imm.12766. Epub 2017 Jun 27.
5
Brain Foxp3 regulatory T cells can be expanded by Interleukin-33 in mouse ischemic stroke.脑内 Foxp3+调节性 T 细胞可被白细胞介素-33 在小鼠脑缺血中扩增。
Int Immunopharmacol. 2020 Apr;81:106027. doi: 10.1016/j.intimp.2019.106027. Epub 2019 Nov 29.
6
Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.表皮生长因子受体（EGFR）配体 Amphiregulin 和 Epiregulin 的交叉抑制以及成纤维细胞生长因子受体 3（FGFR3）信号的去抑制导致野生型 KRAS 肿瘤细胞对西妥昔单抗产生耐药性。
Br J Cancer. 2012 Apr 10;106(8):1406-14. doi: 10.1038/bjc.2012.103.
7
Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone.肺鳞状细胞癌中 Amphiregulin-表皮生长因子受体信号的重建激活了 PTHrP 基因的表达，并促进了癌症引起的骨疾病。
Mol Cancer Res. 2009 Oct;7(10):1714-28. doi: 10.1158/1541-7786.MCR-09-0131. Epub 2009 Oct 13.
8
Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor.成纤维细胞生长因子受体 1 诱导的乳腺肿瘤发生需要表皮生长因子受体的激活。
J Cell Sci. 2011 Sep 15;124(Pt 18):3106-17. doi: 10.1242/jcs.082651. Epub 2011 Aug 24.
9
Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury.Toll 样受体 4 对肠道黏膜损伤的反应中差异调节表皮生长因子相关生长因子。
Lab Invest. 2010 Sep;90(9):1295-305. doi: 10.1038/labinvest.2010.100. Epub 2010 May 24.
10
Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.敲低 Amphiregulin 抑制炎症性乳腺癌中的细胞侵袭。
J Cell Physiol. 2011 Oct;226(10):2691-701. doi: 10.1002/jcp.22620.

引用本文的文献

1
The emerging role of tissue regulatory T cells in tissue repair and regeneration.组织调节性T细胞在组织修复和再生中的新作用。
Front Immunol. 2025 Aug 29;16:1640113. doi: 10.3389/fimmu.2025.1640113. eCollection 2025.
2
Regulatory T Cell Attracting Therapy Accelerates Skeletal Muscle Functional Recovery Following Injury.调节性T细胞吸引疗法可加速损伤后骨骼肌功能恢复。
Res Sq. 2025 Aug 22:rs.3.rs-7237053. doi: 10.21203/rs.3.rs-7237053/v1.
3
Amphiregulin and Fibrosis: Existing Evidence and Future Directions.双调蛋白与纤维化：现有证据及未来方向

本文引用的文献

1
T cell-mediated modulation of mast cell function: heterotypic adhesion-induced stimulatory or inhibitory effects.T 细胞介导的肥大细胞功能调节：异型黏附诱导的刺激或抑制作用。
Front Immunol. 2012 Jan 30;3:6. doi: 10.3389/fimmu.2012.00006. eCollection 2012.
2
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer.鉴定出表皮生长因子受体胞外结构域的一个突变，导致结直肠癌对西妥昔单抗产生耐药性。
Nat Med. 2012 Jan 22;18(2):221-3. doi: 10.1038/nm.2609.
3
Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state.
Int J Mol Sci. 2025 Aug 8;26(16):7678. doi: 10.3390/ijms26167678.
4
Foxp3 Regulatory T Cells Restrain Th1 Response Shielding the Brain from Lethal Inflammatory Damage during Cryptococcal Meningoencephalitis.Foxp3调节性T细胞抑制Th1反应，在新型隐球菌性脑膜脑炎期间保护大脑免受致命性炎症损伤。
Res Sq. 2025 Jul 30:rs.3.rs-7142999. doi: 10.21203/rs.3.rs-7142999/v1.
5
Sensitizing Immune-Refractory Ovarian Tumors via p53 Mutation-Tailored Immunotherapy.通过p53突变定制免疫疗法使免疫难治性卵巢肿瘤致敏
bioRxiv. 2025 Jun 27:2025.06.23.661120. doi: 10.1101/2025.06.23.661120.
6
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants.通过靶向人类肿瘤外植体中的CD38克服免疫治疗耐药性。
Cell Rep Med. 2025 Jul 15;6(7):102210. doi: 10.1016/j.xcrm.2025.102210. Epub 2025 Jun 27.
7
A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma.气道壁的单细胞空间图谱揭示了健康和哮喘状态下的促炎细胞生态系统及其相互作用。
Nat Immunol. 2025 May 21. doi: 10.1038/s41590-025-02161-3.
8
Radiation-induced amphiregulin drives tumour metastasis.辐射诱导的双调蛋白驱动肿瘤转移。
Nature. 2025 May 14. doi: 10.1038/s41586-025-08994-0.
9
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice.维持移植组织驻留的Foxp3+细胞对小鼠肺移植耐受是必要的。
J Clin Invest. 2025 Mar 18;135(10). doi: 10.1172/JCI178975. eCollection 2025 May 15.
10
Treg derived Amphiregulin protects from murine lupus nephritis via tissue reparative effects.调节性T细胞衍生的双调蛋白通过组织修复作用预防小鼠狼疮性肾炎。
Sci Rep. 2025 Mar 5;15(1):7776. doi: 10.1038/s41598-025-91636-2.
被拯救的耐受 CD8 T 细胞被预先编程以重新建立耐受状态。
Science. 2012 Feb 10;335(6069):723-7. doi: 10.1126/science.1214277. Epub 2012 Jan 19.
4
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.TH2 型反应在限制实验性寄生虫感染期间急性组织损伤中的重要作用。
Nat Med. 2012 Jan 15;18(2):260-6. doi: 10.1038/nm.2628.
5
Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis.肥大细胞白细胞介素-2 的产生有助于抑制慢性过敏性皮炎。
Immunity. 2011 Oct 28;35(4):562-71. doi: 10.1016/j.immuni.2011.07.013. Epub 2011 Oct 6.
6
Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment.曲妥珠单抗-多西他赛治疗的头颈部鳞状细胞癌患者中，amphiregulin 和 EGFRvIII 的表达影响预后。
Clin Cancer Res. 2011 Aug 1;17(15):5197-204. doi: 10.1158/1078-0432.CCR-10-3338. Epub 2011 Jun 8.
7
Feedback regulation of EGFR signalling: decision making by early and delayed loops.EGFR 信号反馈调节：早期和延迟反馈环的决策。
Nat Rev Mol Cell Biol. 2011 Feb;12(2):104-17. doi: 10.1038/nrm3048.
8
Human basophils express amphiregulin in response to T cell-derived IL-3.人类嗜碱性粒细胞在 T 细胞衍生的 IL-3 的刺激下表达 Amphiregulin。
J Allergy Clin Immunol. 2010 Dec;126(6):1260-6.e4. doi: 10.1016/j.jaci.2010.08.040. Epub 2010 Oct 30.
9
Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape.肿瘤抗原靶向的、基于单克隆抗体的免疫治疗：临床反应、细胞免疫和免疫逃逸。
J Clin Oncol. 2010 Oct 1;28(28):4390-9. doi: 10.1200/JCO.2009.27.6360. Epub 2010 Aug 9.
10
Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.肥大细胞是前列腺癌中新型的独立预后标志物，是治疗的靶点。
Am J Pathol. 2010 Aug;177(2):1031-41. doi: 10.2353/ajpath.2010.100070. Epub 2010 Jul 8.