Institute of Sport Science and Clinical Biomechanics, Research unit for Exercise Epidemiology, Centre of Research in Childhood Health, University of Southern Denmark, Odense, Denmark.
Scand J Med Sci Sports. 2013 Jun;23(3):e168-77. doi: 10.1111/sms.12046. Epub 2013 Jan 22.
The aim was to investigate the associations between physical activity (PA), cardiorespiratory fitness (CRF) and intima media thickness (IMT) or stiffness. This was a population-based cross-sectional study (n = 336) of Danish adolescents [mean age (standard deviation, SD): 15.6 (0.4) years]. PA intensity was assessed objectively (ActiGraph model GT3X) and CRF using a progressive maximal bicycle test. Carotid IMT and arterial stiffness were assessed using B-mode ultrasound. In a multivariate analysis (adjusted for pubertal development and smoking status), CRF was inversely associated with measures of carotid stiffness (standard beta: -0.20 to -0.15, P < 0.05) in boys, but not in girls. No associations were observed between any of PA and IMT. Boys in the least fit quartile had significantly stiffer carotid arteries compared to the most fit quartile (difference between lowest and highest quartile ranging between 0.4 and 0.5 SD, P < 0.05). This difference in arterial stiffness between low and high quartiles was similar for moderate-to-vigorous PA (MVPA). Further adjustment for sedentary time attenuated the difference observed between quartiles MVPA slightly. Adiposity did not attenuate these differences. Our observations suggest that increasing CRF or MVPA in the least active group of the population may be beneficial for vascular health.
目的在于探究身体活动（PA）、心肺适能（CRF）与内中膜厚度（IMT）或僵硬度之间的关联。这是一项基于人群的丹麦青少年横断面研究（n=336，平均年龄（标准差，SD）：15.6（0.4）岁）。PA 强度通过客观评估（ActiGraph 模型 GT3X）和渐进式最大自行车测试评估 CRF。颈动脉 IMT 和动脉僵硬度通过 B 型超声评估。在多变量分析中（调整青春期发育和吸烟状况），CRF 与男孩颈动脉僵硬度的各项指标呈负相关（标准β：-0.20 至-0.15，P<0.05），但在女孩中没有观察到这种关联。PA 与 IMT 之间没有任何关联。在最不适合的四分位组中，男孩的颈动脉明显比最适合的四分位组僵硬（最低和最高四分位组之间的差异在 0.4 到 0.5 SD 之间，P<0.05）。这种低四分位和高四分位之间的动脉僵硬度差异与中等到剧烈 PA（MVPA）相似。进一步调整久坐时间后，四分位 MVPA 观察到的差异略有减弱。肥胖并不能减弱这些差异。我们的观察结果表明，在人群中最不活跃的群体中增加 CRF 或 MVPA 可能有益于血管健康。
