Discipline of Nutrition, FM&HS, The University of Auckland, Auckland, New Zealand.
BMC Med Genet. 2013 Jan 22;14:10. doi: 10.1186/1471-2350-14-10.
Children born small-for-gestational-age (SGA) are at increased risk of developing obesity and metabolic diseases later in life, a risk which is magnified if followed by accelerated postnatal growth. We investigated whether common gene variants associated with adult obesity were associated with increased postnatal growth, as measured by BMI z-score, in children born SGA and appropriate for gestational age (AGA) in the Auckland Birthweight Collaborative.
A total of 37 candidate SNPs were genotyped on 547 European children (228 SGA and 319 AGA). Repeated measures of BMI (z-score) were used for assessing obesity status, and results were corrected for multiple testing using the false discovery rate.
SGA children had a lower BMI z-score than non-SGA children at assessment age 3.5, 7 and 11 years. We confirmed 27 variants within 14 obesity risk genes to be individually associated with increasing early childhood BMI, predominantly in those born AGA.
Genetic risk variants are less important in influencing early childhood BMI in those born SGA than in those born AGA, suggesting that non-genetic or environmental factors may be more important in influencing childhood BMI in those born SGA.
出生体重小于胎龄儿（SGA）的儿童在以后的生活中患肥胖症和代谢性疾病的风险增加，如果随后出现加速的产后生长，这种风险会更大。我们研究了与成人肥胖相关的常见基因变异是否与通过 BMI z 评分测量的 SGA 和适合胎龄儿（AGA）的儿童的产后生长增加有关，这些儿童都在奥克兰出生体重协作组中。
总共对 547 名欧洲儿童（228 名 SGA 和 319 名 AGA）进行了 37 个候选 SNP 的基因分型。使用 BMI（z 评分）的重复测量来评估肥胖状况，并使用错误发现率对多重检验进行了校正。
SGA 儿童在评估年龄为 3.5、7 和 11 岁时的 BMI z 评分低于非 SGA 儿童。我们在 14 个肥胖风险基因内确认了 27 个变体，这些变体与早期儿童 BMI 的增加有关，主要在 AGA 出生的儿童中。
与 AGA 出生的儿童相比，SGA 出生的儿童的遗传风险变异在影响儿童早期 BMI 方面的重要性较低，这表明非遗传或环境因素可能在影响 SGA 出生的儿童的儿童 BMI 方面更为重要。
