Watanabe S
Epidemiology Division, National Cancer Center Research Institute.
Gan To Kagaku Ryoho. 1990 May;17(5):967-73.
A definition of MPC by IARC and SEER and new methods for determining independent clonality of each MPC were introduced. A trend in frequency of multiple primary cancer (MPC) has been increasing in the National Cancer Center Hospital during 1962-1989. Frequent sites to cause MPC were esophagus (8.4%), larynx (8.2%), bladder (7.9%), colon (7.0%), oro-pharynx (5.5%), and an overall incidence was 2,082/54,888 (3.8%). The association of MPC showed a downstream relationship along the alimentary canal. A common exposure to carcinogenic stimuli in the digestive system was suggested. Smoking tobacco was a risk of frequent oro-pharynx, larynx and lung MPC by a case-control study. Effects of chemotherapy, irradiation and other treatments to cause MPC were introduced. A risk of hormone treatment and immunosuppressive drugs after tissue transplantation was discussed.
介绍了国际癌症研究机构（IARC）和监测、流行病学与最终结果（SEER）对多原发性癌（MPC）的定义以及确定各MPC独立克隆性的新方法。1962年至1989年期间，国立癌症中心医院多原发性癌（MPC）的发生频率呈上升趋势。导致MPC的常见部位为食管（8.4%）、喉（8.2%）、膀胱（7.9%）、结肠（7.0%）、口咽（5.5%），总发病率为2082/54888（3.8%）。MPC的关联在消化道中呈下游关系。提示消化系统存在共同的致癌刺激暴露。一项病例对照研究表明，吸烟是口咽、喉和肺部频繁发生MPC的风险因素。介绍了化疗、放疗及其他治疗导致MPC的影响。讨论了组织移植后激素治疗和免疫抑制药物的风险。
