López Jacqueline, Ruíz Graciela, Organista-Nava Jorge, Gariglio Patricio, García-Carrancá Alejandro
Programa de Doctorado en Ciencias Bioquímicas, Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Open Virol J. 2012;6:232-40. doi: 10.2174/1874357901206010232. Epub 2012 Dec 28.
Different rate of development of productive infections (as low grade cervical intraepithelial neoplasias), or high grade lesions and cervical malignant tumors associated with infections of the Transformation zone (TZ) by High-Risk Human Papillomavirus (HR-HPV), could suggest that different epithelial host target cells could exist. If there is more than one target cell, their differential infection by HR-HPV may play a central role in the development of cervical cancer. Recently, the concept that cancer might arise from a rare population of cells with stem cell-like properties has received support in several solid tumors, including cervical cancer (CC). According to the cancer stem cell (CSC) hypothesis, CC can now be considered a disease in which stem cells of the TZ are converted to cervical cancer stem cells by the interplay between HR-HPV viral oncogenes and cellular alterations that are thought to be finally responsible for tumor initiation and maintenance. Current studies of CSC could provide novel insights regarding tumor initiation and progression, their relation with viral proteins and interplay with the tumor micro-environment. This review will focus on the biology of cervical cancer stem cells, which might contribute to our understanding of the mechanisms responsible for cervical tumor development.
高危型人乳头瘤病毒（HR-HPV）感染转化区（TZ）后，产生不同程度的感染（如低度宫颈上皮内瘤变）、高级别病变及宫颈恶性肿瘤，这可能表明存在不同的上皮宿主靶细胞。如果存在不止一种靶细胞，HR-HPV对它们的差异性感染可能在宫颈癌的发生发展中起核心作用。最近，癌症可能起源于具有干细胞样特性的稀有细胞群体这一概念在包括宫颈癌（CC）在内的几种实体瘤中得到了支持。根据癌症干细胞（CSC）假说，现在可以认为CC是一种疾病，其中TZ的干细胞通过HR-HPV病毒癌基因与细胞改变之间的相互作用转化为宫颈癌干细胞，而这些细胞改变最终被认为是肿瘤起始和维持的原因。目前对CSC的研究可以为肿瘤起始和进展、它们与病毒蛋白的关系以及与肿瘤微环境的相互作用提供新的见解。本综述将聚焦于宫颈癌干细胞的生物学特性，这可能有助于我们理解宫颈肿瘤发生发展的机制。
