Florida State University College of Medicine, Sacred Heart Women's Hospital, Pensacola, Florida, USA.
Obstet Gynecol. 2013 Feb;121(2 Pt 2 Suppl 1):452-4. doi: 10.1097/aog.0b013e31827566ca.
The consequences of intra-amniotic Candida infection can be devastating. Currently, standard management includes delivery. We identified only one previous case reporting intrauterine antifungal therapy, which used transcervical amphotericin B. We present two cases of intra-amniotic Candida infection treated with intra-amniotic fluconazole instilled before membrane rupture.
Two patients presented with intra-amniotic Candida albicans infection that was diagnosed during previability. Both underwent cerclage placement before culture results were available. Aggressive antifungal therapy was instituted using oral, vaginal, and intra-amniotic fluconazole instilled through serial amniocenteses. Both fetuses survived without sequelae.
Intra-amniotic Candida infection is associated with preterm rupture of membranes, preterm labor, severe neonatal infection, and fetal death. Early diagnosis and treatment is essential.
羊膜内念珠菌感染的后果可能是毁灭性的。目前，标准的治疗方法包括分娩。我们只发现了一例以前报告的使用经宫颈两性霉素 B 进行宫内抗真菌治疗的病例。我们报告了两例在胎膜破裂前使用羊膜内氟康唑灌洗治疗的羊膜内念珠菌感染病例。
两名患者在存活前出现羊膜内白色念珠菌感染，在培养结果出来之前就进行了环扎术。通过多次羊膜穿刺术，使用口服、阴道和羊膜内氟康唑进行了积极的抗真菌治疗。两名胎儿均存活且无后遗症。
羊膜内念珠菌感染与胎膜早破、早产、严重新生儿感染和胎儿死亡有关。早期诊断和治疗至关重要。
