Bové Beatriz, Barragán Irene, Pratcorona Laia, Porta Roser, de Diego Raül, Comas Ma Carmen, Méndez María, Gonzalo de Liria Carlos Rodrigo
Department of Obstetrics and Gynaecology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
Department of Pediatrics, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Case Rep Perinat Med. 2025 Jun 11;14(1):20240047. doi: 10.1515/crpm-2024-0047. eCollection 2025 Jan.
Intra-amniotic colonisation or infection caused by is rare. Given the shortage of reported cases, evidence on antifungal strategies and the choice of type and timing of delivery is limited.
We report a case of intra-amniotic colonisation by in a pregnant woman with a previous history of cervical cerclage and candidal vaginosis at 25 weeks of gestational age (GA). The diagnosis was made following preterm premature rupture of membranes at GA 28 weeks and 6 days. Treatment was started with amphotericin B and was replaced by fluconazole due to an anaphylactic reaction. The persistence of in the amniotic fluid after 24 days of treatment prompted the decision to plan an elective caesarean delivery at 32 weeks' GA. The infant showed no signs of fungaemia and had an uneventful clinical course after 14 days of treatment with fluconazole.
Conservative management with intravenous fluconazole in pregnant women with intra-amniotic colonisation by at early GA, can contribute to the prolongation of pregnancy while protecting the foetus from fungal disease.
由[具体病原菌未给出]引起的羊膜腔内定植或感染较为罕见。鉴于报告病例较少，关于抗真菌策略以及分娩类型和时机选择的证据有限。
我们报告一例孕周25周（GA）的孕妇发生羊膜腔内由[具体病原菌未给出]定植的病例，该孕妇既往有宫颈环扎术及念珠菌性阴道炎病史。在孕28周6天时胎膜早破后确诊。治疗开始使用两性霉素B，因过敏反应改用氟康唑。治疗24天后羊水中[具体病原菌未给出]持续存在，促使决定在孕32周行择期剖宫产。婴儿未出现真菌血症迹象，在接受氟康唑治疗14天后临床过程平稳。
对于孕周早期羊膜腔内由[具体病原菌未给出]定植的孕妇，采用静脉注射氟康唑进行保守治疗，可有助于延长孕周，同时保护胎儿免受真菌疾病侵害。
