Dipartimento di Scienze, Università degli Studi della Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Anal Bioanal Chem. 2013 Mar;405(7):2405-10. doi: 10.1007/s00216-013-6706-7. Epub 2013 Jan 24.
We report on the content of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in 15 breast milk samples of nursing women living in the city of Taranto (Southern, Italy) or nearby. Breast milk samples were collected over the 2008-2009 period and analyzed by gas chromatography coupled with high-resolution mass spectrometry (GC-HRMS) upon accelerated solvent extraction (ASE) using acetone/n-hexane mixture 1:1 (v/v). The method was validated demonstrating good performing features. Profiles of PCDD/PCDF congeners in breast milk samples exhibited a prevalence of PCDFs compared to PCDDs. Toxic equivalents (TEQs in picogram per gram fat) of four breast milk were far above the legal limit for human consumption of 3.0 pg/g; their estimated daily and weekly dietary intake were almost 5-20 and 10-40 times higher, respectively, than the tolerable intake values established by the World Health Organization.
我们报告了 15 名居住在意大利南部塔兰托市或附近的哺乳期妇女的母乳样本中多氯二苯并对二恶英（PCDDs）和多氯二苯并呋喃（PCDFs）的含量。在 2008-2009 年期间采集了母乳样本，并通过加速溶剂萃取（ASE）使用丙酮/正己烷混合物 1:1（v/v）进行分析，随后使用气相色谱-高分辨率质谱（GC-HRMS）进行分析。该方法经过验证，表现出良好的性能。母乳样本中 PCDD/PCDF 同系物的分布显示 PCDFs 比 PCDDs 更为普遍。四个母乳样本的毒性当量（TEQ，每克脂肪中的皮克数）远远超过人类消费的 3.0 pg/g 的法定限量；其估计的每日和每周膳食摄入量分别比世界卫生组织制定的可耐受摄入量值高出近 5-20 倍和 10-40 倍。
