Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, 1211 Geneva 4, Switzerland.
J Neurosci. 2013 Jan 23;33(4):1640-50. doi: 10.1523/JNEUROSCI.3530-12.2013.
Although advances have been made regarding how the brain perceives emotional prosody, the neural bases involved in the generation of affective prosody remain unclear and debated. Two models have been forged on the basis of clinical observations: a first model proposes that the right hemisphere sustains production and comprehension of emotional prosody, while a second model proposes that emotional prosody relies heavily on basal ganglia. Here, we tested their predictions in two functional magnetic resonance imaging experiments that used a cue-target paradigm, which allows distinguishing affective from sensorimotor aspects of emotional prosody generation. Both experiments show that when participants prepare for emotional prosody, bilateral ventral striatum is specifically activated and connected to temporal poles and anterior insula, regions in which lesions frequently cause dysprosody. The bilateral dorsal striatum is more sensitive to cognitive and motor aspects of emotional prosody preparation and production and is more strongly connected to the sensorimotor speech network compared with the ventral striatum. Right lateralization during increased prosodic processing is confined to the posterior superior temporal sulcus, a region previously associated with perception of emotional prosody. Our data thus provide physiological evidence supporting both models and suggest that bilateral basal ganglia are involved in modulating motor behavior as a function of affective state. Right lateralization of cortical regions mobilized for prosody control could point to efficient processing of slowly changing acoustic speech parameters in the ventral stream and thus identify sensorimotor processing as an important factor contributing to right lateralization of prosody.
尽管在大脑如何感知情绪韵律方面已经取得了一些进展，但涉及情感韵律产生的神经基础仍不清楚且存在争议。基于临床观察，已经形成了两种模型：第一种模型提出右半球维持情绪韵律的产生和理解，而第二种模型提出情绪韵律严重依赖基底神经节。在这里，我们在两项使用线索-目标范式的功能磁共振成像实验中检验了它们的预测，该范式允许区分情感韵律产生的情感和感觉运动方面。两项实验均表明，当参与者准备情绪韵律时，双侧腹侧纹状体特异性激活，并与颞极和前岛叶相连，这些区域的损伤常导致语调障碍。与腹侧纹状体相比，双侧背侧纹状体对情绪韵律准备和产生的认知和运动方面更为敏感，并且与感觉运动言语网络的连接更为紧密。在增加韵律处理期间的右侧偏侧化仅限于后部上颞回，该区域先前与情绪韵律感知有关。因此，我们的数据提供了支持这两种模型的生理学证据，并表明双侧基底神经节参与调节运动行为以适应情绪状态。用于韵律控制的皮质区域的右侧偏侧化可能指向对缓慢变化的声学语音参数的有效处理，从而将感觉运动处理确定为促进韵律右侧化的重要因素。
