Lindholm C, Hofer P A, Jonsson H
Department of Oncology, University of Umeå, Sweden.
Acta Oncol. 1990;29(2):147-50. doi: 10.3109/02841869009126535.
Histological sections of 50 clinical stage I cutaneous melanomas were analyzed by single cell DNA cytophotometry. Forty-two percent of the melanomas had diploid modal values. Ploidy was not significantly related to the level of invasion, melanoma thickness or prognosis. These results are contradictory to published data from flow cytophotometry which, however, differ inter alia concerning patient materials and follow-up times. Mean nuclear area was in our study significantly correlated to the prognosis.
通过单细胞DNA细胞光度测定法分析了50例临床I期皮肤黑色素瘤的组织学切片。42%的黑色素瘤具有二倍体模态值。倍性与浸润程度、黑色素瘤厚度或预后无显著相关性。这些结果与流式细胞光度测定法公布的数据相矛盾，然而，这些数据在患者材料和随访时间等方面存在差异。在我们的研究中，平均核面积与预后显著相关。
