2004年佩洛塔斯出生队列研究（巴西）中，产妇使用胎儿风险未知药物的情况。
Use of medicines with unknown fetal risk among parturient women from the 2004 Pelotas Birth Cohort (Brazil).
作者信息
Bertoldi Andréa Dâmaso, da Silva Dal Pizzol Tatiane, Camargo Aline Lins, Barros Aluísio J D, Matijasevich Alicia, Santos Iná S
机构信息
Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Rua Marechal Deodoro, 1160, 3 Piso, 96020-220 Pelotas, RS, Brazil.
出版信息
J Pregnancy. 2012;2012:257597. doi: 10.1155/2012/257597. Epub 2012 Dec 31.
BACKGROUND
To estimate the exposure to medicines with unknown fetal risk during pregnancy and to analyze the maternal characteristics associated with it.
METHODS
A questionnaire was administered to 4,189 mothers of children belonging to the 2004 Pelotas (Brazil) birth cohort study about use of any medicine during gestation. We evaluated the associations between use of medicines with unknown fetal risk and the independent variables through logistic regression models. Unknown fetal risk was defined as medicines in which studies in animals have revealed adverse effects on the fetus, and no controlled studies in women, or studies in women and animals, are available.
RESULTS
Out of the 4,189 women, 52.5% used at least one medicine from unknown fetal risk. Use of these medicines was associated with white skin color, high schooling, high income, six or more antenatal care consultations, hospital admission during pregnancy, and morbidity during gestation.
CONCLUSION
The use of unknown fetal risk medicines is high, suggesting that their use must be addressed with caution with the aim of restricting their use to cases in which the benefits are greater than the potential risks.
背景
评估孕期接触胎儿风险未知药物的情况，并分析与之相关的母亲特征。
方法
对2004年巴西佩洛塔斯出生队列研究中4189名儿童的母亲进行问卷调查，询问她们孕期使用任何药物的情况。我们通过逻辑回归模型评估了胎儿风险未知药物的使用与自变量之间的关联。胎儿风险未知被定义为在动物研究中已显示对胎儿有不良影响，但尚无针对女性的对照研究，或尚无针对女性和动物的研究的药物。
结果
在4189名女性中，52.5%至少使用过一种胎儿风险未知的药物。这些药物的使用与白人肤色、高学历、高收入、六次或更多次产前检查、孕期住院以及孕期发病有关。
结论
胎儿风险未知药物的使用较为普遍，这表明必须谨慎对待其使用，目的是将其使用限制在益处大于潜在风险的情况下。
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