Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.
Allergy. 2013 Mar;68(3):274-84. doi: 10.1111/all.12103. Epub 2013 Jan 25.
Over the past two decades, our understanding of eosinophils has evolved from that of categorically destructive effector cells to include active participation in immune modulation, tissue repair processes, and normal organ development, in both health and disease. At the core of their newly appreciated functions is the capacity of eosinophils to synthesize, store within intracellular granules, and very rapidly secrete a highly diverse repertoire of cytokines. Mechanisms governing the selective secretion of preformed cytokines from eosinophils are attractive therapeutic targets and may well be more broadly applicable to other immune cells. Here, we discuss recent advances in deciphering pathways of cytokine secretion, both from intact eosinophils and from tissue-deposited cell-free eosinophil granules, extruded from eosinophils undergoing a lytic cell death.
在过去的二十年中，我们对嗜酸性粒细胞的理解已经从绝对的破坏性效应细胞发展到包括在健康和疾病中积极参与免疫调节、组织修复过程和正常器官发育。它们新的被认可的功能的核心是嗜酸性粒细胞合成、在细胞内颗粒中储存以及非常迅速地分泌高度多样化的细胞因子库的能力。调节嗜酸性粒细胞选择性分泌预先形成的细胞因子的机制是有吸引力的治疗靶点，并且可能更广泛地适用于其他免疫细胞。在这里，我们讨论了阐明细胞因子分泌途径的最新进展，包括从完整的嗜酸性粒细胞和从组织沉积的无细胞嗜酸性粒细胞颗粒中，从经历裂解性细胞死亡的嗜酸性粒细胞中挤出。
