Restorative Dentistry, Leeds Dental Institute.
Br Dent J. 2013 Jan;214(2):E5. doi: 10.1038/sj.bdj.2013.57.
As part of the continuing evolution towards conservative dentistry there has been a drive to push further and investigate the possibility of inducing the repair and regeneration of lost dental hard tissue. Until recently, the prospect of repair and regeneration had been confined to laboratory studies and hypothesised scientific models. In 2009, a new product was launched claiming to be a revolutionary material capable of offering a bioactive and biocompatible replacement for dentine. The calcium-based cement is reported to preserve pulp vitality, promote pulp healing and provide a natural substitute for dentine through bioactive stimulation of the dentino-pulpal complex. Its clinical indications are extensive, described as a restorative material suitable for use wherever dentine replacement is required. In this article the physical, mechanical, chemical and biological properties of this novel material are presented, together with the results of experimental laboratory-based investigations and on-going clinical in vivo investigations.
作为向保守牙科发展的一部分，人们一直在努力探索诱导失去的牙体硬组织修复和再生的可能性。直到最近，修复和再生的前景还局限于实验室研究和假设的科学模型。2009 年，推出了一种新产品，声称是一种革命性的材料，能够为牙本质提供生物活性和生物相容性的替代品。这种基于钙的水泥据称可以保持牙髓活力，促进牙髓愈合，并通过对牙本质牙髓复合体的生物活性刺激提供牙本质的天然替代品。其临床适应证广泛，被描述为一种适合于需要牙本质替代的任何地方使用的修复材料。本文介绍了这种新型材料的物理、机械、化学和生物学特性，以及基于实验的实验室研究和正在进行的临床体内研究的结果。
