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2
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Antioxidant soybean tar Glyteer rescues T-helper-mediated downregulation of filaggrin expression via aryl hydrocarbon receptor.抗氧化大豆焦油Glyteer通过芳烃受体挽救辅助性T细胞介导的丝聚合蛋白表达下调。
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本文引用的文献

1
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.煤焦油诱导特应性皮炎中 AHR 依赖性皮肤屏障修复。
J Clin Invest. 2013 Feb;123(2):917-27. doi: 10.1172/JCI65642. Epub 2013 Jan 25.
2
Advances in atopic dermatitis.特应性皮炎的研究进展。
Curr Opin Immunol. 2011 Dec;23(6):778-83. doi: 10.1016/j.coi.2011.09.007. Epub 2011 Oct 19.
3
Filaggrin mutations associated with skin and allergic diseases.与皮肤和过敏性疾病相关的丝聚合蛋白突变。
N Engl J Med. 2011 Oct 6;365(14):1315-27. doi: 10.1056/NEJMra1011040.
4
DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.煤焦油治疗后银屑病患者和健康志愿者皮肤活检中的 DNA 加合物和尿液中的 1-羟基芘。
Toxicol Lett. 2012 Aug 13;213(1):39-44. doi: 10.1016/j.toxlet.2011.06.030. Epub 2011 Jul 23.
5
An evidence-based review of the efficacy of coal tar preparations in the treatment of psoriasis and atopic dermatitis.煤焦油制剂治疗银屑病和特应性皮炎疗效的循证综述
J Drugs Dermatol. 2010 Oct;9(10):1258-64.
6
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.小鼠Flg基因中的纯合移码突变促进经皮变应原致敏增强。
Nat Genet. 2009 May;41(5):602-8. doi: 10.1038/ng.358. Epub 2009 Apr 6.
7
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.对丝聚合蛋白编码基因的全面分析揭示了寻常型鱼鳞病和特应性皮炎中常见及罕见的突变。
Nat Genet. 2007 May;39(5):650-4. doi: 10.1038/ng2020. Epub 2007 Apr 8.
8
Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.局部用药对人皮肤活体中皮肤药物代谢酶及细胞保护基因表达的调控
Br J Dermatol. 2006 Aug;155(2):275-81. doi: 10.1111/j.1365-2133.2006.07317.x.
9
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.表皮屏障蛋白丝聚合蛋白常见的功能丧失变异是特应性皮炎的主要诱发因素。
Nat Genet. 2006 Apr;38(4):441-6. doi: 10.1038/ng1767. Epub 2006 Mar 19.
10
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.编码丝聚合蛋白的基因功能丧失性突变会导致寻常型鱼鳞病。
Nat Genet. 2006 Mar;38(3):337-42. doi: 10.1038/ng1743. Epub 2006 Jan 29.

老煤王——特应性皮炎古老疗法的分子机制。

Old King coal - molecular mechanisms underlying an ancient treatment for atopic eczema.

机构信息

Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, College of Life Sciences and Medicine, Dentistry and Nursing, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

出版信息

J Clin Invest. 2013 Feb;123(2):551-3. doi: 10.1172/JCI67438. Epub 2013 Jan 25.

DOI:10.1172/JCI67438
PMID:23348733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3561843/
Abstract

Traditional remedies for common disorders have been known for centuries, but insight into their mechanism of action is often limited. In this issue of the JCI, Joost Schalkwijk's research group at the Radboud University Nijmegen Medical Centre in The Netherlands advances our understanding of why topical coal tar is an effective treatment for atopic dermatitis (AD), both rationalizing the use of this traditional medicine, and providing the scientific basis for new therapeutic approaches.

摘要

传统的治疗常见疾病的方法已经存在了几个世纪，但是对于其作用机制的了解往往是有限的。在本期 JCI 中，荷兰奈梅亨拉德堡德大学医学中心的 Joost Schalkwijk 研究小组深入研究了为什么局部煤焦油是治疗特应性皮炎（AD）的有效方法，这不仅使这种传统药物的使用合理化，而且为新的治疗方法提供了科学依据。