Research Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, United Kingdom.
Psychoneuroendocrinology. 2013 Sep;38(9):1484-93. doi: 10.1016/j.psyneuen.2012.12.015. Epub 2013 Jan 25.
Sleep duration and quality are associated with adverse physical health outcomes. The mechanisms are not well understood, and little is known about associations with biomarkers in older population cohorts. This study assessed cross-sectional associations between self-reported sleep measures and biomarkers in a representative sample of British people aged 50 years and above. Participants were 6465 men and women aged 50-99 years from the English Longitudinal Study of Ageing (ELSA). Associations of sleep duration and sleep disturbance with C-reactive protein (CRP), fibrinogen, dehydroepiandrosterone sulfate (DHEAS) and hemoglobin were analyzed, adjusting for age, wealth, body mass index (BMI), smoking, physical activity, limiting long-standing illness and depressive symptoms. In men, long sleep duration (OR: 1.50, 1.05-2.14) and greater sleep disturbance (OR: 1.29, C.I. 1.05-1.59) were associated with raised CRP levels, while long sleep was also related to raised plasma fibrinogen (P=0.001). DHEAS levels were lower among men reporting more sleep disturbances (P=0.016), but were not related to sleep duration. Sleep duration (P=0.015) and sleep disturbance (P=0.039) were associated with lower hemoglobin levels, and anemia was more prevalent among men with disturbed sleep (OR: 1.73, C.I. 1.13-2.65). In women more disturbed sleep was associated with greater likelihood of anemia (OR: 1.59, C.I. 1.02-2.46), but there was no relationship between sleep disturbance or duration with other biomarkers. This study suggests that self-reported sleep duration and disturbance are related to biological risk factors in community-dwelling older adults, with different associations being present in men and women. A better understanding of these relationships using longitudinal cohort studies will broaden our understanding of the mechanisms relating sleep indices and ill health in advancing age.
睡眠时长和质量与不良身体健康结果有关。其机制尚不清楚，对于老年人群队列中与生物标志物的关联也知之甚少。本研究评估了自我报告的睡眠测量值与英国 50 岁及以上人群代表性样本中生物标志物之间的横断面关联。参与者为来自英国老龄化纵向研究（ELSA）的 6465 名 50-99 岁的男性和女性。分析了睡眠时长和睡眠障碍与 C 反应蛋白（CRP）、纤维蛋白原、脱氢表雄酮硫酸盐（DHEAS）和血红蛋白之间的关联，调整了年龄、财富、体重指数（BMI）、吸烟、身体活动、长期限制疾病和抑郁症状。在男性中，长睡眠时长（OR：1.50，1.05-2.14）和更大的睡眠障碍（OR：1.29，CI 1.05-1.59）与 CRP 水平升高相关，而长睡眠也与血浆纤维蛋白原升高有关（P=0.001）。报告睡眠障碍较多的男性 DHEAS 水平较低（P=0.016），但与睡眠时长无关。睡眠时长（P=0.015）和睡眠障碍（P=0.039）与较低的血红蛋白水平相关，睡眠障碍的男性更易发生贫血（OR：1.73，CI 1.13-2.65）。在女性中，更多的睡眠障碍与贫血的可能性更大相关（OR：1.59，CI 1.02-2.46），但睡眠障碍或时长与其他生物标志物之间没有关系。本研究表明，自我报告的睡眠时长和障碍与社区居住的老年成年人的生物风险因素有关，男性和女性之间存在不同的关联。使用纵向队列研究更好地了解这些关系将拓宽我们对与睡眠指数和高龄不良健康相关的机制的理解。
