终生伴侣：RNA 解旋酶及其在 RNA 代谢中的作用。
Lifelong companions: RNA helicases and their roles in RNA metabolism.
机构信息
Institute for Physical Chemistry, University of Muenster, Muenster, Germany.
出版信息
RNA Biol. 2013 Jan;10(1):2-3. doi: 10.4161/rna.23500. Epub 2013 Jan 1.
Abstract
The life of an RNA molecule is complicated. Once a newly synthesized eukaryotic RNA has emerged from the RNA polymerase in the nucleus, it will be processed, spliced, and exported into cytoplasm. In prokaryotes, transcribed RNA is synthesized directly in the cytoplasm. RNA molecules that serve as mRNAs have to be kept devoid of local structures that are inhibitory for ribosome scanning and translation. Quite differently, structural and catalytic RNAs have to adopt a defined three-dimensional conformation to exert their biological function, and may assemble with other protein and/or RNA partners into complex functional units. Ultimately, RNA degradation by the so-called degradosome will end the RNA's life.
摘要
RNA 分子的生命是复杂的。一旦新合成的真核 RNA 从核内的 RNA 聚合酶中出现，它将被加工、剪接，并输出到细胞质中。在原核生物中，转录 RNA 直接在细胞质中合成。作为 mRNA 的 RNA 分子必须保持没有抑制核糖体扫描和翻译的局部结构。相反，结构和催化 RNA 必须采用特定的三维构象才能发挥其生物学功能，并可能与其他蛋白质和/或 RNA 伴侣组装成复杂的功能单元。最终，所谓的降解体通过 RNA 降解将结束 RNA 的生命。
相似文献
1
Lifelong companions: RNA helicases and their roles in RNA metabolism.终生伴侣：RNA 解旋酶及其在 RNA 代谢中的作用。
RNA Biol. 2013 Jan;10(1):2-3. doi: 10.4161/rna.23500. Epub 2013 Jan 1.
2
Recognition of the 70S ribosome and polysome by the RNA degradosome in Escherichia coli.在大肠杆菌中，RNA 降解体对 70S 核糖体和多核糖体的识别。
Nucleic Acids Res. 2012 Nov 1;40(20):10417-31. doi: 10.1093/nar/gks739. Epub 2012 Aug 25.
3
RNA helicases: diverse roles in prokaryotic response to abiotic stress.RNA 解旋酶：在原核生物应对非生物胁迫中的多种作用。
RNA Biol. 2013 Jan;10(1):96-110. doi: 10.4161/rna.22638. Epub 2012 Oct 23.
4
RNA helicases in RNA decay.RNA 解旋酶在 RNA 衰变中的作用。
Biochem Soc Trans. 2018 Feb 19;46(1):163-172. doi: 10.1042/BST20170052. Epub 2018 Jan 19.
5
The RNase J-Based RNA Degradosome Is Compartmentalized in the Gastric Pathogen Helicobacter pylori.基于 RNase J 的 RNA 降解体在胃病原体幽门螺杆菌中是分隔的。
mBio. 2020 Sep 15;11(5):e01173-20. doi: 10.1128/mBio.01173-20.
6
Yeast and human mitochondrial helicases.酵母和人类线粒体解旋酶。
Biochim Biophys Acta. 2013 Aug;1829(8):842-53. doi: 10.1016/j.bbagrm.2013.02.009. Epub 2013 Feb 27.
7
DExD/H box RNA helicases: from generic motors to specific dissociation functions.DExD/H盒RNA解旋酶：从通用马达到特定解离功能
Mol Cell. 2001 Aug;8(2):251-62. doi: 10.1016/s1097-2765(01)00329-x.
8
Rarely at rest: RNA helicases and their busy contributions to RNA degradation, regulation and quality control.很少休息：RNA 解旋酶及其在 RNA 降解、调控和质量控制中的繁忙贡献。
RNA Biol. 2013 Jan;10(1):56-70. doi: 10.4161/rna.22270. Epub 2012 Oct 12.
9
Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases.解旋酶、分解酶与传感器：RNA解旋酶的结构与功能生物化学故事
Int J Mol Sci. 2015 Jan 22;16(2):2269-93. doi: 10.3390/ijms16022269.
10
DExD/H-box RNA helicases in ribosome biogenesis.DExD/H 框 RNA 解旋酶在核糖体生物发生中的作用。
RNA Biol. 2013 Jan;10(1):4-18. doi: 10.4161/rna.21879. Epub 2012 Aug 24.
引用本文的文献
1
The DEAD-Box Protein Rok1 Coordinates Ribosomal RNA Processing in Association with Rrp5 in .DEAD-Box 蛋白 Rok1 通过与 Rrp5 相关联来协调核糖体 RNA 加工。
Int J Mol Sci. 2022 May 19;23(10):5685. doi: 10.3390/ijms23105685.
2
A DEAD-box protein acts through RNA to promote HIV-1 Rev-RRE assembly.一种DEAD盒蛋白通过RNA发挥作用，促进HIV-1 Rev-RRE组装。
Nucleic Acids Res. 2017 May 5;45(8):4632-4641. doi: 10.1093/nar/gkx206.
3
The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation.DEAD盒蛋白Rok1通过促进Rrp5从40S前核糖体释放以利于60S成熟来协调40S和60S核糖体组装。
PLoS Biol. 2016 Jun 9;14(6):e1002480. doi: 10.1371/journal.pbio.1002480. eCollection 2016 Jun.
4
RNA Helicase Important for Listeria monocytogenes Hemolytic Activity and Virulence Factor Expression.RNA解旋酶对单核细胞增生李斯特菌溶血活性和毒力因子表达至关重要。
Infect Immun. 2015 Oct 19;84(1):67-76. doi: 10.1128/IAI.00849-15. Print 2016 Jan.
5
HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.HrpA，一种参与 RNA 加工的 RNA 解旋酶，是莱姆病螺旋体感染小鼠和传播给蜱的必需蛋白。
PLoS Pathog. 2013;9(12):e1003841. doi: 10.1371/journal.ppat.1003841. Epub 2013 Dec 19.
本文引用的文献
1
DEAD box RNA helicase functions in cancer.无脊椎动物 DEAD box RNA 解旋酶在癌症中的功能。
RNA Biol. 2013 Jan;10(1):121-32. doi: 10.4161/rna.23312. Epub 2013 Jan 1.
2
Helicase-mediated changes in RNA structure at the single-molecule level.在单分子水平上通过解旋酶介导的 RNA 结构变化。
RNA Biol. 2013 Jan;10(1):133-48. doi: 10.4161/rna.23507. Epub 2013 Jan 1.
3
Characterization of the kinetics of RNA annealing and strand displacement activities of the E. coli DEAD-box helicase CsdA.解析大肠杆菌 DEAD-box 解旋酶 CsdA 的 RNA 退火和链置换活性的动力学特征。
RNA Biol. 2013 Jan;10(1):149-56. doi: 10.4161/rna.23475. Epub 2013 Jan 1.
4
RNA helicases in splicing.RNA 解旋酶在剪接中的作用。
RNA Biol. 2013 Jan;10(1):83-95. doi: 10.4161/rna.22547. Epub 2012 Dec 10.
5
The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus.CshA DEAD-box RNA 解旋酶对金黄色葡萄球菌群体感应的控制很重要。
RNA Biol. 2013 Jan;10(1):157-65. doi: 10.4161/rna.22899. Epub 2012 Dec 10.
6
Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing.双链 RNA 激活的 ATP 酶 (DRAs)：RNA 感应、信号转导和加工的平台。
RNA Biol. 2013 Jan;10(1):111-20. doi: 10.4161/rna.22706. Epub 2012 Dec 10.
7
RNA helicases: diverse roles in prokaryotic response to abiotic stress.RNA 解旋酶：在原核生物应对非生物胁迫中的多种作用。
RNA Biol. 2013 Jan;10(1):96-110. doi: 10.4161/rna.22638. Epub 2012 Oct 23.
8
Rarely at rest: RNA helicases and their busy contributions to RNA degradation, regulation and quality control.很少休息：RNA 解旋酶及其在 RNA 降解、调控和质量控制中的繁忙贡献。
RNA Biol. 2013 Jan;10(1):56-70. doi: 10.4161/rna.22270. Epub 2012 Oct 12.
9
Mss116p: a DEAD-box protein facilitates RNA folding.Mss116p：一种 DEAD 框蛋白促进 RNA 折叠。
RNA Biol. 2013 Jan;10(1):71-82. doi: 10.4161/rna.22492. Epub 2012 Oct 12.
10
The DEAD-box helicase eIF4A: paradigm or the odd one out?DEAD-box 解旋酶 eIF4A：范例还是异类？
RNA Biol. 2013 Jan;10(1):19-32. doi: 10.4161/rna.21966. Epub 2012 Sep 20.
Zotero 插件