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饮茶与骨密度的最新关联:一项荟萃分析。

Updated association of tea consumption and bone mineral density: A meta-analysis.

作者信息

Zhang Zhao-Fei, Yang Jun-Long, Jiang Huan-Chang, Lai Zheng, Wu Feng, Liu Zhi-Xiang

机构信息

Department of Orthopedic Surgery, Huadu District People's Hospital of Guangzhou, Guangdong, China.

出版信息

Medicine (Baltimore). 2017 Mar;96(12):e6437. doi: 10.1097/MD.0000000000006437.

Abstract

BACKGROUND

Current studies evaluating the association of tea consumption and bone mineral density (BMD) have yielded inconsistent findings. Therefore, we conducted a meta-analysis to assess the relationship between tea consumption and BMD.

METHODS

The PubMed, Embase, and Cochrane Library databases were comprehensively searched, and a meta-analysis performed of all observational studies assessing the association of tea consumption and BMD. Forest plots were used to illustrate the results graphically. The Q-test and I statistic were employed to evaluate between-study heterogeneity. Potential publication bias was assessed by the funnel plot.

RESULTS

Four cohort, 1 case-control, and 8 cross-sectional studies including a total of 12,635 cases were included. Tea consumption was shown to prevent bone loss [odds ratio (OR): 0.66; 95% confidence interval (CI), 0.47-0.94; P = 0.02], yielding higher mineral densities in several bones, including the lumbar spine [standardized mean difference (SMD): 0.19; 95% CI, 0.08-0.31; P = 0.001], hip (SMD: 0.19; 95% CI, 0.05-0.34; P = 0.01), femoral neck [mean difference (MD): 0.01; 95% CI, 0.00-0.02; P = 0.04], Ward triangle (MD: 0.02; 95% CI, 0.01-0.04; P = 0.001), and greater trochanter (MD: 0.03; 95% CI, 0.02-0.04; P < 0.00001), than the non-tea consumption group.

CONCLUSION

This meta-analysis provided a potential trend that tea consumption might be beneficial for BMD, especially in the lumbar spine, hip, femoral neck, Ward triangle, and greater trochanter, which might help prevent bone loss.

摘要

背景

目前评估饮茶与骨密度(BMD)之间关联的研究结果并不一致。因此,我们进行了一项荟萃分析,以评估饮茶与骨密度之间的关系。

方法

全面检索了PubMed、Embase和Cochrane图书馆数据库,并对所有评估饮茶与骨密度关联的观察性研究进行了荟萃分析。森林图用于以图形方式说明结果。采用Q检验和I统计量评估研究间的异质性。通过漏斗图评估潜在的发表偏倚。

结果

纳入了四项队列研究、一项病例对照研究和八项横断面研究,共12,635例。结果显示,饮茶可预防骨质流失[比值比(OR):0.66;95%置信区间(CI),0.47 - 0.94;P = 0.02],在包括腰椎[标准化均值差(SMD):0.19;95% CI,0.08 - 0.31;P = 0.001]、髋部(SMD:0.19;95% CI,0.05 - 0.34;P = 0.01)、股骨颈[均值差(MD):0.01;95% CI,0.00 - 0.02;P = 0.04]、Ward三角区(MD:0.02;95% CI,0.01 - 0.04;P = 0.001)和大转子(MD:0.03;95% CI,0.02 - 0.04;P < 0.00001)在内的几块骨骼中产生更高的矿物质密度,高于不饮茶组。

结论

这项荟萃分析提供了一个潜在趋势,即饮茶可能对骨密度有益,尤其是在腰椎、髋部、股骨颈、Ward三角区和大转子,这可能有助于预防骨质流失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4e/5371490/bc00ee8282cf/medi-96-e6437-g001.jpg

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