Clinical Education, Innovative Therapies, Inc., Gaithersburg, MD 20877, USA.
J Wound Ostomy Continence Nurs. 2013 Mar-Apr;40(2):143-9. doi: 10.1097/WON.0b013e31827e8481.
Biofilms are communities of microbes that exist in a variety of environments. The extracellular substances secreted by biofilms make them difficult to eradicate, giving the bacterial community in the biofilm a resistance advantage over freefloating (planktonic) microbes. Biofilms are particularly problematic in chronic wounds because of their resistance to conventional therapies and tendency to delay healing. Multimodal strategies to combat wound biofilms are necessary, including wound debridement, antimicrobial treatment, and continued disruption of biofilms. Negative pressure wound therapy with irrigation or instillation may lower the bacterial burden in chronic wounds and prevent the biofilm formation. This article provides an overview of biofilms and evolving strategies to counteract them.
生物膜是存在于多种环境中的微生物群落。生物膜分泌的细胞外物质使其难以根除，使生物膜中的细菌群落比游离（浮游）微生物具有更强的耐药优势。生物膜在慢性伤口中尤其成问题，因为它们对传统疗法有抵抗力，并且容易延迟愈合。需要采取多模式策略来对抗伤口生物膜，包括清创、抗菌治疗和持续破坏生物膜。负压伤口治疗加冲洗或滴注可能会降低慢性伤口中的细菌负担并防止生物膜形成。本文概述了生物膜和对抗它们的策略。
