利用磁驱动微悬臂梁在工程化微组织中解耦细胞和基质力学。
Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers.
机构信息
Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Adv Mater. 2013 Mar 25;25(12):1699-705. doi: 10.1002/adma.201203585. Epub 2013 Jan 28.
Abstract
A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.
摘要
一种新型的生物磁机械微组织系统被描述用于使用微悬臂梁对 3D 微组织阵列进行磁驱动。该系统能够原位测量工程组织的基本机械性能，如收缩性和刚性，以及对微组织的动态刺激。使用该系统，在静态和动态加载条件下，首次实现了细胞和细胞外基质对组织机械性能的解耦。
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