Kumar Ajay, Behen Michael E, Singsoonsud Piti, Veenstra Amy L, Wolfe-Christensen Cortney, Helder Emily, Chugani Harry T
1Carmen and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, USA.
J Child Neurol. 2014 Mar;29(3):318-25. doi: 10.1177/0883073812474098. Epub 2013 Jan 28.
This study utilized diffusion tensor imaging fiber tractography to examine the miscrostructural integrity of limbic and paralimbic white matter tracts in 36 children (age M = 124 months) with histories of early deprivation, raised from birth in orphanages and subsequently adopted into the United States, compared to 16 age-matched typically developing children. We found increased mean diffusivity bilaterally in the arcuate fasciculus and increased mean diffusivity and reduced fractional anisotropy bilaterally in the uncinate fasciculus and cingulum in children with early deprivation. Microstructural integrity of the left arcuate fasciculus and right cingulum was related to language and behavioral functioning, respectively. White matter abnormalities were also associated with length of deprivation and time in the adoptive home. Our findings suggest that white matter pathways, connecting limbic and paralimbic brain regions is abnormal in children with histories of early deprivation, with some pathways appearing more susceptible to early deprivation than others.
本研究利用扩散张量成像纤维束示踪技术，对36名有早期剥夺史的儿童（平均年龄M = 124个月，出生后在孤儿院长大，随后被收养到美国）与16名年龄匹配的正常发育儿童的边缘和边缘旁白质束的微观结构完整性进行了检查。我们发现，早期剥夺儿童的双侧弓状束平均扩散率增加，双侧钩束和扣带束的平均扩散率增加，分数各向异性降低。左侧弓状束和右侧扣带束的微观结构完整性分别与语言和行为功能相关。白质异常也与剥夺时间和收养家庭中的时间有关。我们的研究结果表明，有早期剥夺史的儿童连接边缘和边缘旁脑区的白质通路异常，一些通路比其他通路更容易受到早期剥夺的影响。
