Sarici Dilek, Akin Mustafa Ali, Kurtoglu Selim, Akin Leyla, Tucer Bulent, Yikilmaz Ali, Gokoglu Abdulkerim
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Childs Nerv Syst. 2013 Jun;29(6):1027-30. doi: 10.1007/s00381-013-2038-3. Epub 2013 Jan 29.
Iodine deficiency is the most devastating event in developing brain in the fetus and neonate. Iodine is absolutely necessary on the myelination, neuronal differentiation, and formation of neural processes, synaptogenesis, and neuronal migration by thyroidal hormones throughout pregnancy and shortly after birth. Neural tube defects (NTD) form after third and fourth gestational weeks and their etiologies are multifactorial.
We herein present a male newborn with iodine deficiency and thoracic neuroenteric cyst bound to a myelomeningocele via a pedinculi. We hypothesize that iodine deficiency may be a cause of NTD, and iodine supplementation in preconception and pregnancy may prevent NTD.
碘缺乏是胎儿和新生儿发育中大脑最具破坏性的事件。在整个孕期及出生后不久，甲状腺激素对于髓鞘形成、神经元分化、神经突起形成、突触发生和神经元迁移而言，碘是绝对必需的。神经管缺陷（NTD）在妊娠第三和第四周后形成，其病因是多因素的。
我们在此报告一名患有碘缺乏症的男性新生儿，其胸段神经肠囊肿通过蒂与脊髓脊膜膨出相连。我们推测碘缺乏可能是神经管缺陷的一个原因，孕前和孕期补充碘可能预防神经管缺陷。
