Petrichenko O, Erglis K, Cēbers A, Plotniece A, Pajuste K, Béalle G, Ménager Ch, Dubois E, Perzynski R
University of Latvia, Zeļļu-8, LV-1002, Rıga, Latvia.
Eur Phys J E Soft Matter. 2013 Jan;36(1):9. doi: 10.1140/epje/i2013-13009-0. Epub 2013 Jan 30.
We synthesize giant magnetic liposomes by a reverse-phase evaporation method (REV) using a new self-assembling Cationic Pyridine Amphiphile (CPA) derived from 1,4-dihydropyridine as liposome-forming agent and a magnetic ferrofluid based on γ-Fe(2)O(3) nanoparticles. Having in view the potential interest of CPA in targeted transport by magnetic forces, the mechanical elastic properties of such bilayers are here directly investigated in vesicles loaded with magnetic nanoparticles. Bending elastic modulus K(b) ∼ 0.2 to 5k(B)T and pre-stress τ ∼ 3.2 to 12.10(-6) erg/cm(2) are deduced from the under-field deformations of the giant magnetic liposomes. The obtained K(b) values are discussed in terms of A. Wurgers's theory.
我们使用一种新的自组装阳离子吡啶两亲物（CPA）作为脂质体形成剂，通过反相蒸发法（REV）合成了巨型磁性脂质体，该阳离子吡啶两亲物由1,4 - 二氢吡啶衍生而来，并使用了基于γ-Fe(2)O(3)纳米颗粒的磁性铁流体。鉴于CPA在磁力靶向运输方面的潜在应用价值，本文直接研究了负载磁性纳米颗粒的囊泡中此类双层膜的机械弹性特性。从巨型磁性脂质体的低场变形推导出弯曲弹性模量K(b)约为0.2至5k(B)T，预应力τ约为3.2至12×10^(-6) erg/cm(2)。根据A. Wurgers理论对获得的K(b)值进行了讨论。
