Méan Marie, Righini Marc, Jaeger Kurt, Beer Hans-Jürg, Frauchiger Beat, Osterwalder Joseph, Kucher Nils, Lämmle Bernhard, Cornuz Jacques, Angelillo-Scherrer Anne, Rodondi Nicolas, Limacher Andreas, Trelle Sven, Matter Christian M, Husmann Marc, Banyai Martin, Aschwanden Markus, Egloff Michael, Mazzolai Lucia, Hugli Olivier, Bounameaux Henri, Aujesky Drahomir
Division of General Internal Medicine, Bern University Hospital, Inselspital, 3010, Bern, Switzerland,
J Thromb Thrombolysis. 2013 Nov;36(4):475-83. doi: 10.1007/s11239-013-0875-2.
Venous thromboembolism (VTE) is common and has a high impact on morbidity, mortality, and costs of care. Although most of the patients with VTE are aged ≥65 years, there is little data about the medical outcomes in the elderly with VTE. The Swiss Cohort of Elderly Patients with VTE (SWITCO65+) is a prospective multicenter cohort study of in- and outpatients aged ≥65 years with acute VTE from all five Swiss university and four high-volume non-university hospitals. The goal is to examine which clinical and biological factors and processes of care drive short- and long-term medical outcomes, health-related quality of life, and medical resource utilization in elderly patients with acute VTE. The cohort also includes a large biobank with biological material from each participant. From September 2009 to March 2012, 1,863 elderly patients with VTE were screened and 1003 (53.8%) were enrolled in the cohort. Overall, 51.7% of patients were aged ≥75 years and 52.7% were men. By October 16, 2012, after an average follow-up time of 512 days, 799 (79.7%) patients were still actively participating. SWITCO65+ is a unique opportunity to study short- and long-term outcomes in elderly patients with VTE. The Steering Committee encourages national and international collaborative research projects related to SWITCO65+, including sharing anonymized data and biological samples.
静脉血栓栓塞症（VTE）很常见，对发病率、死亡率和护理成本有很大影响。虽然大多数VTE患者年龄≥65岁，但关于老年VTE患者医疗结局的数据却很少。瑞士老年VTE患者队列研究（SWITCO65+）是一项前瞻性多中心队列研究，研究对象为来自瑞士所有五所大学医院和四所大型非大学医院的年龄≥65岁的急性VTE门诊和住院患者。其目的是研究哪些临床和生物学因素以及护理过程会影响老年急性VTE患者的短期和长期医疗结局、健康相关生活质量以及医疗资源利用情况。该队列还包括一个大型生物样本库，其中存有每位参与者的生物样本。从2009年9月至2012年3月，对1863例老年VTE患者进行了筛查，1003例（53.8%）被纳入该队列。总体而言，51.7%的患者年龄≥75岁，52.7%为男性。到2012年10月16日，平均随访时间为512天后，799例（79.7%）患者仍在积极参与研究。SWITCO65+是研究老年VTE患者短期和长期结局的一个独特机会。指导委员会鼓励开展与SWITCO65+相关的国内和国际合作研究项目，包括共享匿名数据和生物样本。
