两株耐碳青霉烯类肺炎克雷伯菌爆发株的荚膜多糖和脂多糖结构。
The capsular polysaccharide and lipopolysaccharide structures of two carbapenem resistant Klebsiella pneumoniae outbreak isolates.
机构信息
Program on Developmental and Molecular Immunity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, United States.
出版信息
Carbohydr Res. 2013 Mar 22;369:6-9. doi: 10.1016/j.carres.2012.12.018. Epub 2012 Dec 29.
Abstract
Carbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: The LPS of the two isolates was found to have no O-specific polysaccharide and the chemical structure of the core oligosaccharides agreed with the published data. If this structure type will be prevalent among CPKP isolates, our findings could facilitate rapid diagnosis and help to develop new therapeutic solutions to this antibiotic resistant pathogen.
摘要
耐碳青霉烯类肺炎克雷伯菌（CRKP）的分离频率正在不断增加，尤其是在免疫功能低下的患者中。CPKP 的荚膜多糖（CPS）类型尚未确定。对 2011 年美国国立卫生研究院临床中心爆发疫情的两株 CRKP 分离株的调查发现，两株分离株具有一种新的荚膜型，与肺炎克雷伯菌 K19 和 K34 相似，但与任何已发表的肺炎克雷伯菌 CPS 重复单元在结构上不同：两株分离株的 LPS 没有 O-特异性多糖，核心寡糖的化学结构与已发表的数据一致。如果这种结构类型在 CPKP 分离株中普遍存在，我们的发现可以促进快速诊断，并有助于针对这种抗生素耐药病原体开发新的治疗解决方案。
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