Troyk Philip R, Mushahwar Vivian K, Stein Richard B, Suh Sungjae, Everaert Dirk, Holinski Brad, Hu Zhe, DeMichele Glenn, Kerns Douglas, Kayvani Kevin
Illinois institute of Technology, Chicago, IL 60616, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:900-3. doi: 10.1109/EMBC.2012.6346077.
This paper reports on a wireless stimulator device for use in animal experiments as part of an ongoing investigation into intraspinal stimulation (ISMS) for restoration of walking in humans with spinal cord injury. The principle behind using ISMS is the activation of residual motor-control neural networks within the spinal cord ventral horn below the level of lesion following a spinal cord injury. The attractiveness to this technique is that a small number of electrodes can be used to induce bilateral walking patterns in the lower limbs. In combination with advanced feedback algorithms, ISMS has the potential to restore walking for distances that exceed that produced by other types of functional electrical stimulation. Recent acute animal experiments have demonstrated the feasibility of using ISMS to produce the coordinated walking patterns. Here we described a wireless implantable stimulation system to be used in chronic animal experiments and for providing the basis for a system suitable for use in humans. Electrical operation of the wireless system is described, including a demonstration of reverse telemetry for monitoring the stimulating electrode voltages.
本文报道了一种用于动物实验的无线刺激器装置，该装置是正在进行的一项关于脊髓内刺激（ISMS）以恢复脊髓损伤患者行走能力研究的一部分。使用ISMS背后的原理是激活脊髓损伤后损伤平面以下脊髓腹角内残留的运动控制神经网络。这项技术的吸引力在于可以使用少量电极在下肢诱发双侧行走模式。结合先进的反馈算法，ISMS有潜力恢复超过其他类型功能性电刺激所产生距离的行走能力。最近的急性动物实验已经证明了使用ISMS产生协调行走模式的可行性。在此，我们描述了一种用于慢性动物实验的无线植入式刺激系统，并为适用于人类的系统提供基础。文中描述了该无线系统的电气操作，包括用于监测刺激电极电压的反向遥测演示。
