利用超材料传输线结构在微波频段对微流控通道进行同步介电监测。

Simultaneous dielectric monitoring of microfluidic channels at microwaves utilizing a metamaterial transmission line structure.

作者信息

Schüßler M, Puentes M, Dubuc D, Grenier K, Jakoby R

机构信息

Technische Universität Darmstadt, Institute of Microwave Engineering and Photonics, Merckstrasse 25, D-64283 Darmstadt, Germany.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6273-6. doi: 10.1109/EMBC.2012.6347428.

DOI:10.1109/EMBC.2012.6347428

PMID:23367363

Abstract

The paper presents a technique that allows the simultaneous monitoring of the dielectric properties of liquids in microfluidic channels at microwave frequencies. It is capable of being integrated within the lab-on-a-chip concept and uses a composite right/left-handed transmission line resonator which is detuned by the dielectric loading of the liquids in the channels. By monitoring the change in the resonance spectrum of the resonator the loading profile can be derived with the multi-resonant perturbation method. From the value of the dielectric constant inference on the substances like cells or chemicals in the channels can be drawn. The paper presents concept, design, fabrication and characterization of prototype sensors. The sensors have been designed to operate between 20 and 30 GHz and were tested with water and water ethanol mixtures.

摘要

本文介绍了一种能够在微波频率下同时监测微流控通道中液体介电特性的技术。该技术能够集成到芯片实验室概念中，并使用一种复合左右手传输线谐振器，该谐振器会因通道中液体的介电负载而失谐。通过监测谐振器谐振频谱的变化，可采用多谐振微扰法得出负载分布。根据介电常数的值，可以推断通道中细胞或化学物质等物质的情况。本文介绍了原型传感器的概念、设计、制造和特性。这些传感器设计用于在20至30GHz之间运行，并用水和水乙醇混合物进行了测试。