基于微波共面波导传输线的 40GHz RF 生物传感器用于癌细胞（HepG2）介电特性表征。

40 GHz RF biosensor based on microwave coplanar waveguide transmission line for cancer cells (HepG2) dielectric characterization.

机构信息

Department of Photonics, National Cheng Kung University, No. 1, University Road, Tainan City, 701, Taiwan.

Department of Computer and Communication, Kun Shan University, No. 195, Kunda Road, YongKang District, Tainan City, 710-03, Taiwan.

出版信息

Biosens Bioelectron. 2014 Nov 15;61:417-21. doi: 10.1016/j.bios.2014.05.060. Epub 2014 Jun 6.

DOI:10.1016/j.bios.2014.05.060

PMID:24934741

Abstract

This paper presents a 40-GHz RF biosensor that involves using a microwave coplanar waveguide (CPW) transmission line for the dielectric characterization of cancer cells (Hepatoma G2, HepG2). In the past, conventional resonator-based biosensors were designed to operate at a specific resonant peak; however, the dielectric sensitivity of the cells was restricted to a narrow bandwidth. To provide a very wide bandwidth (1-40 GHz), biosensors were based on a microwave CPW transmission line. The proposed biosensor can rapidly measure two frequency-dependent cell-based dielectric parameters of HepG2 cells, microwave attenuation (α(f)cell) and the dielectric constant (εr(f)cell), while removing the microwave parasitic effects (including the cultured medium and substrate materials). The proposed biosensor can be applied in postoperative cancer diagnosis.

摘要

本文提出了一种 40GHz 的射频生物传感器，该传感器使用微波共面波导（CPW）传输线对癌细胞（肝癌 G2，HepG2）进行介电特性表征。过去，基于传统谐振器的生物传感器被设计为在特定谐振峰处工作；然而，细胞的介电灵敏度被限制在很窄的带宽内。为了提供非常宽的带宽（1-40GHz），生物传感器基于微波 CPW 传输线。所提出的生物传感器可以快速测量 HepG2 细胞的两个基于微波的细胞介电参数，即微波衰减（α（f）cell）和介电常数（εr（f）cell），同时消除微波寄生效应（包括培养基和衬底材料）。所提出的生物传感器可应用于癌症术后诊断。