Nikkilä M, Heikkinen J
Department of Clinical Sciences, University of Tampere, Finland.
Age Ageing. 1990 Mar;19(2):119-24. doi: 10.1093/ageing/19.2.119.
Serum total cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides were studied in three groups: (1) 85 healthy subjects aged 85-89 years, (2) 62 patients without coronary artery disease aged 38-62 years, and (3) 323 patients aged 32-69 years with triple-vessel disease diagnosed by coronary angiography. The mean values for total cholesterol were significantly higher in patients with triple-vessel disease than in those without coronary artery disease and in the elderly. Total cholesterol was over 6.5 mmol/l in 32% of the elderly, in 31% of patients without coronary artery disease and in 42% of patients with triple-vessel disease, but these differences were not significant. HDL-cholesterol and the ratio of HDL/total cholesterol were significantly higher in the elderly than in the patients without coronary artery disease and patients with triple-vessel disease. Serum HDL-cholesterol was over 1.0 mmol/l in 92% of the elderly, in 69% of patients without coronary artery disease and in 46% of patients with triple-vessel disease, the differences being significant between all groups.
对三组人群的血清总胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯进行了研究：（1）85名年龄在85至89岁的健康受试者；（2）62名年龄在38至62岁且无冠状动脉疾病的患者；（3）323名年龄在32至69岁且经冠状动脉造影诊断为三支血管病变的患者。三支血管病变患者的总胆固醇平均值显著高于无冠状动脉疾病的患者和老年人。32%的老年人、31%无冠状动脉疾病的患者以及42%三支血管病变的患者总胆固醇超过6.5 mmol/l，但这些差异并不显著。老年人的HDL胆固醇以及HDL/总胆固醇比值显著高于无冠状动脉疾病的患者和三支血管病变的患者。92%的老年人、69%无冠状动脉疾病的患者以及46%三支血管病变的患者血清HDL胆固醇超过1.0 mmol/l，所有组之间的差异具有显著性。
