David T J, Wells F E, Sharpe T C, Gibbs A C, Devlin J
Department of Child Health, University of Manchester, U.K.
Br J Dermatol. 1990 Apr;122(4):485-9. doi: 10.1111/j.1365-2133.1990.tb14725.x.
The hypothesis that atopic eczema is associated with a non-specific decrease in the serum concentration of trace metals was examined by measurement of the levels of zinc, copper and iron in 134 children with atopic eczema and 112 controls. The results failed to confirm the hypothesis. There was no significant difference between patients and controls for the concentrations of serum zinc, iron, iron-binding capacity and albumin. Patients with eczema had a significantly higher copper concentration (median 21.0 mumol/l) than controls (median 17.0 mumol/l), and a significantly lower concentration of ferritin (median 11.9 ng/ml for patients and 16.5 ng/ml for controls). There was a highly significant correlation between the surface area of skin affected by eczema and the concentrations of albumin and orosomucoid.
通过测量134名特应性湿疹患儿和112名对照儿童的锌、铜和铁水平，对特应性湿疹与血清中痕量金属浓度非特异性降低相关这一假说进行了检验。结果未能证实这一假说。患者与对照在血清锌、铁、铁结合能力及白蛋白浓度方面无显著差异。湿疹患者的铜浓度（中位数21.0μmol/L）显著高于对照（中位数17.0μmol/L），而铁蛋白浓度显著低于对照（患者中位数11.9ng/ml，对照中位数16.5ng/ml）。湿疹受累皮肤面积与白蛋白及类粘蛋白浓度之间存在高度显著相关性。
