两个不同的慢性开角型青光眼群体的生物统计学证据。
Biostatistical evidence for two distinct chronic open angle glaucoma populations.
作者信息
Schulzer M, Drance S M, Carter C J, Brooks D E, Douglas G R, Lau W
机构信息
University of British Columbia, Department of Statistics, Vancouver, Canada.
出版信息
Br J Ophthalmol. 1990 Apr;74(4):196-200. doi: 10.1136/bjo.74.4.196.
Abstract
Twenty-six eyes of 26 patients with low-tension glaucoma and 34 eyes of 34 patients with high-tension glaucoma were studied. Fifty-one measurements were available on each patient, including visual field indices, finger blood flow measurements, as well as haematological, coagulation, and biochemical and rheological variables. Multivariate analysis revealed two statistically distinct groups of patients, with low and high tension glaucoma cases equally distributed in both. The smaller group (15 patients) showed a suggestion of vasospastic finger blood flow measurements, and had a high positive correlation between the mean deviation (MD) index of field severity and the highest intraocular pressure (r = 0.715, p = 0.0008). The second, larger group (45 patients) showed disturbed coagulation and biochemical measurements, suggestive of vascular disease, and had no correlation between the MD index and the highest intraocular pressure.
摘要
对26例低眼压性青光眼患者的26只眼和34例高眼压性青光眼患者的34只眼进行了研究。对每位患者进行了51项测量，包括视野指标、手指血流测量，以及血液学、凝血、生化和流变学变量。多变量分析显示出两组在统计学上有明显差异的患者，低眼压性青光眼和高眼压性青光眼病例在两组中分布均匀。较小的一组（15例患者）显示出手指血流测量有血管痉挛的迹象，且视野严重程度的平均偏差（MD）指数与最高眼压之间存在高度正相关（r = 0.715，p = 0.0008）。第二组，即较大的一组（45例患者）显示出凝血和生化测量结果异常，提示有血管疾病，且MD指数与最高眼压之间无相关性。
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