Haasio J, Jokinen T, Numminen M, Rosenberg P H
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Br J Oral Maxillofac Surg. 1990 Apr;28(2):99-101. doi: 10.1016/0266-4356(90)90131-4.
The analgesic effect of topical application of local anaesthetics on the gingival mucosa and the absorption of the local anaesthetics into the blood were investigated in healthy volunteers by using a 5% eutectic mixture of the local anaesthetics lignocaine (100 mg) and prilocaine (100 mg) plus emulsifier (EMLA) or 10% lignocaine (200 mg) spray (Xylocain). The pain threshold on labial gingiva was measured by using the stimulator of an EMG-apparatus and a pair of stimulating electrodes, specially constructed for this purpose. There were no differences between the two methods in producing analgesia which was at its maximum in 13 to 14 minutes, on average. Sensation of the gingiva (pain thresholds), had usually returned to normal within 30 minutes. In the dosages used, the absorption of the local anaesthetics was more rapid after the mixture application than after spray application. No toxic reactions occurred.
通过使用局部麻醉药利多卡因（100毫克）和丙胺卡因（100毫克）加乳化剂（EMLA）的5%共晶混合物或10%利多卡因（200毫克）喷雾剂（赛罗卡因），在健康志愿者中研究了局部麻醉药局部应用于牙龈黏膜的镇痛效果以及局部麻醉药的血液吸收情况。使用肌电图仪的刺激器和为此专门构建的一对刺激电极来测量唇侧牙龈的疼痛阈值。两种方法在产生镇痛效果方面没有差异，平均在13至14分钟时达到最大镇痛效果。牙龈的感觉（疼痛阈值）通常在30分钟内恢复正常。在所使用的剂量下，混合物应用后局部麻醉药的吸收比喷雾剂应用后更快。未发生毒性反应。
