Lang Xinrui, Qiao Bo, Ge Ziyu, Yan Jiahui, Zhang Yanzhen
Department of General Dentistry, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
J Clin Med. 2022 Nov 28;11(23):7042. doi: 10.3390/jcm11237042.
Several clinical trials have recently been conducted to elucidate the effectiveness of photofunctionalization. The aim of this review was to systematically analyze the clinical effects of photofunctionalization on implant stability and marginal bone loss (MBL).
An electronic search in four databases and a manual search were conducted in September 2022. Randomized controlled trials (RCTs), clinical controlled trials (CCTs), and cohort and case-control studies evaluating the effects of photofunctionalization on implant stability or marginal bone loss (MBL) in humans were included. The methodological quality assessment using RoB 2.0 and the ROBINS-I tool was performed based on different study designs.
Seven studies were included for a qualitative analysis, and five of them were chosen for a meta-analysis. The meta-analysis revealed that photofunctionalization significantly improved the stability of the implant 2 months after implantation ( = 0.04; MD = 3.48; 95% CI = -0.23 to 6.73) and increased the osseointegration speed index (OSI) ( = 0.007; MD = 2.13; 95% CI = 0.57 to 3.68). However, no significant improvements of implant stability were observed 2 weeks ( = 0.62), 4 weeks ( = 0.31), nor 4 months ( = 0.24) after implantation. The evaluation presented no significant reductions in MBL.
Based on the positive effect of photofunctionalization on the rate of establishing implant stability, photofunctionalization may provide an effective and practical strategy to achieve faster osseointegration and reduce the overall healing time. Photofunctionalization appears to improve the implant stability. However, the clinical effect of photofunctionalization on MBL remains unclear due to the shortage of available studies.
最近进行了多项临床试验以阐明光功能化的有效性。本综述的目的是系统分析光功能化对种植体稳定性和边缘骨丢失（MBL）的临床效果。
2022年9月进行了四个数据库的电子检索和手动检索。纳入评估光功能化对人类种植体稳定性或边缘骨丢失（MBL）影响的随机对照试验（RCT）、临床对照试验（CCT）以及队列和病例对照研究。根据不同的研究设计，使用RoB 2.0和ROBINS - I工具进行方法学质量评估。
纳入七项研究进行定性分析，其中五项被选入荟萃分析。荟萃分析显示，光功能化在植入后2个月时显著提高了种植体的稳定性（P = 0.04；MD = 3.48；95%CI = -0.23至6.73），并提高了骨结合速度指数（OSI）（P = 0.007；MD = 2.13；95%CI = 0.57至3.68）。然而，在植入后2周（P = 0.62）、4周（P = 0.31）和4个月（P = 0.24）时，未观察到种植体稳定性有显著改善。评估显示MBL没有显著降低。
基于光功能化对建立种植体稳定性速率的积极影响，光功能化可能提供一种有效且实用的策略，以实现更快的骨结合并减少整体愈合时间。光功能化似乎能提高种植体稳定性。然而，由于现有研究不足，光功能化对MBL的临床效果仍不明确。
