Fort P, Moses N, Fasano M, Goldberg T, Lifshitz F
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
J Am Coll Nutr. 1990 Apr;9(2):164-7. doi: 10.1080/07315724.1990.10720366.
It has been suggested that feeding practices in infancy may affect the development of various autoimmune diseases later in life. Since thyroid alterations are among the most frequently encountered autoimmune conditions in children, we studied whether breast and soy-containing formula feedings in early life were associated with the subsequent development of autoimmune thyroid disease. A detailed history of feeding practices was obtained in 59 children with autoimmune thyroid disease, their 76 healthy siblings, and 54 healthy nonrelated control children. There was no difference in the frequency and duration of breast feeding in early life among the three groups of children. However, the frequency of feedings with soy-based milk formulas in early life was significantly higher in children with autoimmune thyroid disease (prevalence 31%) as compared with their siblings (prevalence 12%; chi 2 = 7.22 with continuity factor; p less than 0.01), and healthy nonrelated control children (prevalence 13%, chi 2 = 5.03 with continuity factor; p less than 0.02). Therefore, this retrospective analysis documents the association of soy formula feedings in infancy and autoimmune thyroid disease.
有人提出，婴儿期的喂养方式可能会影响日后各种自身免疫性疾病的发展。由于甲状腺改变是儿童中最常见的自身免疫性疾病之一，我们研究了生命早期的母乳喂养和含大豆配方奶喂养是否与自身免疫性甲状腺疾病的后续发展有关。我们获取了59名患有自身免疫性甲状腺疾病的儿童、他们的76名健康兄弟姐妹以及54名健康的非亲属对照儿童的详细喂养史。三组儿童在生命早期母乳喂养的频率和持续时间上没有差异。然而，患有自身免疫性甲状腺疾病的儿童在生命早期食用大豆配方奶的频率（患病率31%）显著高于其兄弟姐妹（患病率12%；连续性校正卡方值=7.22；p<0.01）和健康的非亲属对照儿童（患病率13%，连续性校正卡方值=5.03；p<0.02）。因此，这项回顾性分析证明了婴儿期食用大豆配方奶与自身免疫性甲状腺疾病之间的关联。
