Department of Diagnostic and Interventional Radiology, University Hospital, RWTH Aachen University, Aachen, Germany.
Invest Radiol. 2013 Apr;48(4):231-7. doi: 10.1097/RLI.0b013e3182809143.
The aim of this study was to investigate if 3.0-T diffusion-weighted magnetic resonance imaging (MRI) can be used for early detection of acute occlusive and nonocclusive mesenteric ischemia.
In this study, approved by the official committee on animal affairs, proximal (occlusive) mesenteric ischemia and peripheral (nonocclusive) mesenteric ischemia were induced in 8 and 2, respectively, female domestic pigs. Proximal mesenteric ischemia was induced by intra-arterial injection of n-butyl-cyanoacrylate in the superior mesenteric artery or 1 of its main branches; peripheral mesenteric ischemia was induced by intra-arterial injection of microparticles. Before embolization and at 30-, 60-, and 90-minute intervals after embolization, diffusion-weighted imaging was performed, and apparent diffusion coefficient (ADC) maps were calculated on a clinical 3.0-T system. Immediately after the last MRI session, animals were killed to provide a pathological correlation for mesenteric ischemia.
Ischemic bowel parts appeared hyperintense on diffusion-weighted images and hypointense on the corresponding ADC maps. Mean diffusion-weighted imaging signal intensity increased and ADC decreased significantly within 30 minutes after embolization (P < 0.001) and remained unchanged until 90 minutes after injury, independent of the embolization method.
3.0-Tesla diffusion-weighted MRI may help detect acute mesenteric ischemia as early as 30 minutes after vessel occlusion.
本研究旨在探讨 3.0T 扩散加权磁共振成像（MRI）是否可用于早期检测急性闭塞性和非闭塞性肠系膜缺血。
在这项经动物事务官方委员会批准的研究中，分别通过向肠系膜上动脉或其主要分支内注射正丁基氰基丙烯酸酯（occlusive 肠系膜缺血）或微球（peripheral 肠系膜缺血）诱导近端（闭塞性）和外周（非闭塞性）肠系膜缺血。在栓塞前以及栓塞后 30、60 和 90 分钟，在临床 3.0T 系统上进行扩散加权成像，并计算表观扩散系数（ADC）图。在最后一次 MRI 检查后立即处死动物，以提供肠系膜缺血的病理相关性。
缺血肠段在扩散加权图像上呈高信号，在相应的 ADC 图上呈低信号。栓塞后 30 分钟内，弥散加权成像信号强度增加，ADC 值显著降低（P < 0.001），并且在损伤后 90 分钟内保持不变，与栓塞方法无关。
3.0T 弥散加权 MRI 可能有助于在血管闭塞后 30 分钟内尽早检测急性肠系膜缺血。
