Natural Product Microbes, Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, India.
J Nat Prod. 2013 Feb 22;76(2):194-9. doi: 10.1021/np3006666. Epub 2013 Feb 6.
From an endophytic fungus, a close relative of Talaromyces sp., found in association with Cedrus deodara, four compounds including two new ones (2 and 4) were isolated and characterized. The structures of two compounds (1 and 4) were confirmed by X-ray crystallography. The compounds displayed a range of cytotoxicities against human cancer cell lines (HCT-116, A-549, HEP-1, THP-1, and PC-3). All the compounds were found to induce apoptosis in HL-60 cells, as evidenced by fluorescence and scanning electron microscopy studies. Also, the compounds caused significant microtubule inhibition in HL-60 cells.
从与雪松共生的拟青霉属真菌中分离得到了四个化合物，包括两个新化合物（2 和 4）。通过 X 射线晶体学确定了两个化合物（1 和 4）的结构。这些化合物对人癌细胞系（HCT-116、A-549、HEP-1、THP-1 和 PC-3）表现出广泛的细胞毒性。荧光和扫描电子显微镜研究表明，所有化合物均能诱导 HL-60 细胞凋亡。此外，这些化合物还能显著抑制 HL-60 细胞中的微管。
