Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), Av. Normalistas 800, Guadalajara, Jalisco 44270, Mexico.
Food Funct. 2013 Apr 25;4(4):618-26. doi: 10.1039/c3fo30270a. Epub 2013 Feb 7.
The growing incidence of obesity is a worldwide public health problem leading to a risk factor for non-alcoholic fatty liver disease, which extends from steatosis to steatohepatitis and cirrhosis. We investigated whether the aqueous extract of Hibiscus sabdariffa L. (Hs) reduces body weight gain and protects the liver by improving lipid metabolism in high fat diet-induced obese C57BL/6NHsd mice. We found that oral administration of the Hs extract reduced fat tissue accumulation, diminished body weight gain and normalized the glycemic index as well as reduced dyslipidemia compared to the obese mice group that did not receive Hs treatment. In addition, Hs treatment attenuated liver steatosis, down-regulated SREBP-1c and PPAR-γ, blocked the increase of IL-1, TNF-α mRNA and lipoperoxidation and increased catalase mRNA. Our results suggest that the anti-obesity, anti-lipidemic and hepatoprotective effects of the Hs extract are related to the regulation of PPAR-γ and SREBP-1c in the liver.
肥胖症发病率的上升是一个全球性的公共卫生问题，导致非酒精性脂肪性肝病的风险因素增加，这种疾病从脂肪变性扩展到脂肪性肝炎和肝硬化。我们研究了罗望子（Hibiscus sabdariffa L.）的水提取物是否通过改善高脂肪饮食诱导的肥胖 C57BL/6NHsd 小鼠的脂质代谢来减轻体重增加并保护肝脏。我们发现，与未接受 Hs 治疗的肥胖小鼠组相比，口服 Hs 提取物可减少脂肪组织积累，减轻体重增加并使血糖指数正常化，同时降低血脂异常。此外，Hs 治疗可减轻肝脂肪变性，下调 SREBP-1c 和 PPAR-γ，阻断 IL-1、TNF-α mRNA 和脂质过氧化的增加，并增加过氧化氢酶 mRNA。我们的结果表明，Hs 提取物的抗肥胖、抗血脂和保肝作用与肝脏中 PPAR-γ 和 SREBP-1c 的调节有关。
