不同临床亚型口腔扁平苔藓患者血清血管内皮生长因子水平
Serum Level of Vascular Endothelial Growth Factor in Patients with Different Clinical SubtypeS of Oral Lichen Planus.
作者信息
Mardani Maryam, Ghabanchi Jannan, Fattahi Mohammad Javad, Tadbir Azadeh Andisheh
机构信息
Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran;
出版信息
Iran J Med Sci. 2012 Dec;37(4):233-7.
BACKGROUND
Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal individuals and consider its clinical significance.
METHODS
In this case-control study, 36 serum samples from patients diagnosed with oral lichen planus admitted to the Oral Medicine Department of the School of Dentistry at Shiraz University of Medical Sciences (14 men, 22 women, mean [±SD] age: 38.8 [±6.07] years) and 23 serum samples from healthy individuals (9 men, 14 women, mean [±SD] age: 38.7 [±4.9] years) were collected. VEGF concentration was measured using the ELISA method. The Mann-Whitney test was used for statistical analysis.
RESULTS
The serum VEGF level was significantly higher in patients with oral lichen planus compared with the healthy controls (112.97 [±63.2] vs. 66.21 [±56.2] ngr/ml, P<0.001). A similar difference was also observed between the two types of oral lichen planus, being more pronounced in the erosive form (P<0.001).
CONCLUSION
Serum VEGF can be used as a useful and suitable marker to scrutinize the disease activity.
背景
口腔扁平苔藓是一种病因不明的慢性炎症性疾病。血管生成在不同慢性炎症性疾病发展中的作用备受关注。血管内皮生长因子（VEGF）是血管生成的重要调节因子。我们旨在评估口腔扁平苔藓患者与正常个体相比的血清VEGF水平，并探讨其临床意义。
方法
在这项病例对照研究中，收集了设拉子医科大学牙科学院口腔内科收治的36例口腔扁平苔藓患者的血清样本（14例男性，22例女性，平均[±标准差]年龄：38.8[±6.07]岁）和23例健康个体的血清样本（9例男性，14例女性，平均[±标准差]年龄：38.7[±4.9]岁）。采用酶联免疫吸附测定（ELISA）法测定VEGF浓度。采用曼-惠特尼检验进行统计分析。
结果
与健康对照组相比，口腔扁平苔藓患者的血清VEGF水平显著更高（112.97[±63.2]对66.21[±56.2]ngr/ml，P<0.001）。两种类型的口腔扁平苔藓之间也观察到类似差异，在糜烂型中更为明显（P<0.001）。
结论
血清VEGF可作为监测疾病活动的有用且合适的标志物。
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