Pomerantz S M
Department of Physiology, University of Pittsburgh School of Medicine, PA 15261.
Pharmacol Biochem Behav. 1990 Mar;35(3):659-64. doi: 10.1016/0091-3057(90)90304-z.
In the present study, a novel sexual behavior paradigm was used to study the effects of the dopamine agonist, apomorphine, on male sexual behavior of rhesus monkeys. In Experiment 1, the effects of apomorphine treatment were assessed by observing the behavioral responses of male rhesus to a sexually receptive female monkey that they could see, hear, and smell, but could not physically contact. Apomorphine treatment produced a spectrum of behavioral effects that differed depending on the dose of drug administered. Low doses of apomorphine (25-100 micrograms/kg) stimulated yawning, moderate doses (50-200 micrograms/kg) facilitated male sexual responses associated with the genitals including penile erection and masturbation, and high doses (greater than 200 micrograms/kg) elicited stereotypic behavior. Experiment 2 examined whether the behavioral responses of male monkeys to apomorphine treatment were influenced by the stimulus female. Apomorphine treatment facilitated penile erections in tests in which a stimulus female was present, but did not facilitate erections in tests in which she was absent. In sum, these experiments provide preliminary evidence that dopaminergic mechanisms may play a role in the regulation of male sexual behavior of rhesus monkeys.
在本研究中，采用了一种新的性行为范式来研究多巴胺激动剂阿扑吗啡对恒河猴雄性性行为的影响。在实验1中，通过观察雄性恒河猴对一只它们能看到、听到和闻到，但无法身体接触的处于性接受期的雌性猴子的行为反应，来评估阿扑吗啡治疗的效果。阿扑吗啡治疗产生了一系列行为效应，这些效应因给药剂量的不同而有所差异。低剂量的阿扑吗啡（25 - 100微克/千克）刺激打哈欠，中等剂量（50 - 200微克/千克）促进与生殖器相关的雄性性反应，包括阴茎勃起和自慰，而高剂量（大于200微克/千克）引发刻板行为。实验2检验了雄性猴子对阿扑吗啡治疗的行为反应是否受刺激雌性的影响。在有刺激雌性在场的测试中，阿扑吗啡治疗促进了阴茎勃起，但在她不在场的测试中则没有促进勃起。总之，这些实验提供了初步证据，表明多巴胺能机制可能在恒河猴雄性性行为的调节中起作用。
