Schmidt E B, Varming K, Ernst E, Madsen P, Dyerberg J
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Thromb Haemost. 1990 Feb 19;63(1):1-5.
We have studied the dose-response effects of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA's) on lipids and haemostasis. Ten healthy males were each given 1.3 g, 4 g or 9 g of n-3 PUFA's daily for 6-week periods. Bleeding time, HDL-cholesterol and plasminogen activator inhibitor increased with the dose of n-3 PUFA. Plasma fibrinogen and triglyceride levels were reduced in a dose-dependent fashion. After ingestion of 1.3 g of n-3 PUFA's plasma fibrinogen decreased from 9 to 7 mumol/l and HDL-cholesterol increased from 1.2 to 1.3 mmol/l. The bleeding time was prolonged from 5 to 6.5 min while triglyceride levels decreased from 1.2 to 0.9 mmol/l after ingestion of 4 g of n-3 PUFA's. Dietary supplementation with the highest daily dose (9 g) reduced plasma levels of triglycerides, fibrinogen and von Willebrand factor, while bleeding time, plasminogen activator antigen, plasminogen activator inhibitor and the ratio of HDL-cholesterol to total cholesterol increased.
我们研究了膳食补充n-3多不饱和脂肪酸（n-3 PUFA）对脂质和止血的剂量反应效应。10名健康男性每人每天分别给予1.3克、4克或9克n-3 PUFA，为期6周。出血时间、高密度脂蛋白胆固醇（HDL-胆固醇）和纤溶酶原激活物抑制剂随n-3 PUFA剂量增加而升高。血浆纤维蛋白原和甘油三酯水平呈剂量依赖性降低。摄入1.3克n-3 PUFA后，血浆纤维蛋白原从9微摩尔/升降至7微摩尔/升，HDL-胆固醇从1.2毫摩尔/升升至1.3毫摩尔/升。摄入4克n-3 PUFA后，出血时间从5分钟延长至6.5分钟，而甘油三酯水平从1.2毫摩尔/升降至0.9毫摩尔/升。每日最高剂量（9克）的膳食补充降低了血浆甘油三酯、纤维蛋白原和血管性血友病因子水平，而出血时间、纤溶酶原激活物抗原、纤溶酶原激活物抑制剂以及HDL-胆固醇与总胆固醇的比值升高。
