Schmidt E B, Ernst E, Varming K, Pedersen J O, Dyerberg J
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Thromb Haemost. 1989 Sep 29;62(2):797-801.
Plasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A1 decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type IIa and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.
对17例高脂血症患者在补充6克n-3脂肪酸6周前后的血浆脂质和止血情况进行了研究。其中9例患者为IIa型高脂血症，8例为IV型高脂血症。未观察到对血浆胆固醇、低密度脂蛋白胆固醇或高密度脂蛋白胆固醇有影响，但补充n-3脂肪酸后血浆甘油三酯降低。补充油剂后载脂蛋白B升高，载脂蛋白A1降低。出血时间延长，但n-3脂肪酸对血小板聚集无影响。补充后IIa型患者蛋白C活性增加，IV型患者蛋白C活性降低。摄入n-3脂肪酸后纤维蛋白溶解明显受抑制，而血管性血友病因子抗原减少。
