Institute for Sport and Health, School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.
Cell Metab. 2013 Feb 5;17(2):162-84. doi: 10.1016/j.cmet.2012.12.012.
Preservation of aerobic fitness and skeletal muscle strength through exercise training can ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated in part by extensive metabolic and molecular remodeling of skeletal muscle by exercise. Aerobic and resistance exercise represent extremes on the exercise continuum and elicit markedly different training responses that are mediated by a complex interplay between a myriad of signaling pathways coupled to downstream regulators of transcription and translation. Here, we review the metabolic responses and molecular mechanisms that underpin the adaptatation of skeletal muscle to acute exercise and exercise training.
通过运动训练来保持有氧适能和骨骼肌力量，可以改善代谢功能障碍，预防慢性疾病。这些益处部分是通过运动对骨骼肌进行广泛的代谢和分子重塑来介导的。有氧运动和抗阻运动代表了运动连续体的两个极端，它们通过无数信号通路与转录和翻译下游调控因子之间的复杂相互作用，引起明显不同的训练反应。在这里，我们回顾了骨骼肌对急性运动和运动训练适应的代谢反应和分子机制。
