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梅毒:肾病综合征的一个可逆病因。

Syphilis: a reversible cause of nephrotic syndrome.

作者信息

Handoko M Louis, Duijvestein Marjolijn, Scheepstra Cornelis G, de Fijter Carola W H

机构信息

Department of Internal Medicine/Nephrology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.

出版信息

BMJ Case Rep. 2013 Feb 8;2013:bcr2012008279. doi: 10.1136/bcr-2012-008279.

DOI:10.1136/bcr-2012-008279
PMID:23396933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3604415/
Abstract

A patient in his late 30s presented with symptoms consistent with a nephrotic syndrome. Renal biopsy revealed membranous nephropathy. He also mentioned a spontaneous resolving 'rash' at his glans penis after unprotected intercourse. Therefore, he was tested for sexually transmitted diseases as a possible underlying cause of his nephrotic syndrome. Serology for syphilis was positive with high titres. After a single penicillin injection, there was fast and complete clinical recovery.

摘要

一名30多岁的男性患者出现了符合肾病综合征的症状。肾活检显示为膜性肾病。他还提到在无保护性行为后,龟头出现了自行消退的“皮疹”。因此,对他进行了性传播疾病检测,以寻找其肾病综合征可能的潜在病因。梅毒血清学检测呈高滴度阳性。单次注射青霉素后,患者临床迅速且完全康复。

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Syphilis: a reversible cause of nephrotic syndrome.梅毒:肾病综合征的一个可逆病因。
BMJ Case Rep. 2013 Feb 8;2013:bcr2012008279. doi: 10.1136/bcr-2012-008279.
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A 17-year-old male with nephrotic syndrome and diffuse adenopathy: questions.一名患有肾病综合征和弥漫性腺病的17岁男性:问题。
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[Syphilitic glomerulonephritis: case report and review of the literature].[梅毒性肾小球肾炎:病例报告及文献复习]
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Secondary syphilis: a rare cause of nephrotic syndrome.二期梅毒:肾病综合征的罕见病因。
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[Lupus nephropathy with positive syphilis serology, difficult differentiation from renal involvement in syphilis].梅毒血清学阳性的狼疮性肾炎,与梅毒肾损害难以鉴别
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CEN Case Rep. 2025 May 14. doi: 10.1007/s13730-025-00997-0.
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A case of neuron-derived neurotrophic factor-positive, syphilis-related membranous nephropathy that achieved spontaneous remission.一例神经元源性神经营养因子阳性、梅毒相关膜性肾病自发缓解的病例。
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本文引用的文献

1
Hepatitis B virus related membranous glomerulonephritis and proteinuria treated with lamivudine and tenofovir.拉米夫定和替诺福韦治疗乙型肝炎病毒相关性膜性肾小球肾炎及蛋白尿
BMJ Case Rep. 2011 Aug 31;2011:bcr0520114287. doi: 10.1136/bcr.05.2011.4287.
2
Simultaneous acute nephrosis and hepatitis in secondary syphilis.二期梅毒并发急性肾病和肝炎
Clin Nephrol. 2008 Dec;70(6):532-6. doi: 10.5414/cnp70532.
3
Clinical challenges and images in GI. Syphilitic sigmoiditis complicated by membranous nephropathy.胃肠病学临床挑战与影像。梅毒相关性乙状结肠炎合并膜性肾病。
Gastroenterology. 2008 Aug;135(2):363, 716. doi: 10.1053/j.gastro.2008.06.055. Epub 2008 Jul 9.
4
Nephrotic syndrome in adults.成人肾病综合征
BMJ. 2008 May 24;336(7654):1185-9. doi: 10.1136/bmj.39576.709711.80.
5
Syphilis.梅毒
BMJ. 2007 Jan 20;334(7585):143-7. doi: 10.1136/bmj.39085.518148.BE.
6
Secondary syphilis and the nephrotic syndrome.二期梅毒与肾病综合征。
J Am Soc Nephrol. 1993 Jan;3(7):1351-5. doi: 10.1681/ASN.V371351.
7
Syphilis--a reversible cause of nephrotic syndrome in HIV infection.梅毒——人类免疫缺陷病毒感染中肾病综合征的一个可逆病因。
N Engl J Med. 1991 Jan 31;324(5):341-2.
8
Secondary syphilis presenting as nephrotic syndrome.表现为肾病综合征的二期梅毒。
West J Med. 1992 Jun;156(6):654-5.