INSERM, U1077, CHU Avenue de la Côte de Nacre, CS 30001, 14033 Caen Cedex 9, Caen, France.
Nat Rev Neurol. 2013 Mar;9(3):123-4. doi: 10.1038/nrneurol.2013.21. Epub 2013 Feb 12.
The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.
淀粉样蛋白级联假说认为，β-淀粉样蛋白的积累是阿尔茨海默病神经退行性变的关键事件，该假说主导该领域已有 20 年。然而，最近的发现表明，神经元损伤生物标志物与β-淀粉样蛋白无关，这就要求重新考虑病理级联，并评估替代治疗策略。
