Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Trends Endocrinol Metab. 2013 Apr;24(4):200-8. doi: 10.1016/j.tem.2013.01.002. Epub 2013 Feb 8.
Highly proliferative cells, including cancer cells, require a constant supply of molecular building blocks to support their growth. To acquire substrates such as glucose and amino acids from the extracellular space, dividing cells rely on transporter proteins in the plasma membrane. Numerous studies link transcriptional and post-translational control of nutrient transporter expression with proliferation, highlighting the importance of nutrient transporters in both physiologic and pathologic growth. Here we review recent work that spotlights the crucial role of nutrient transporters in cell growth and proliferation, discuss post-translational mechanisms for coordinating expression of different transporters, and consider the therapeutic potential of targeting these proteins in cancer and other diseases characterized by inappropriate cell division.
高度增殖的细胞,包括癌细胞,需要不断供应分子构建块来支持其生长。为了从细胞外空间获取葡萄糖和氨基酸等底物,分裂细胞依赖于质膜中的转运蛋白。大量研究将营养物转运蛋白的转录和翻译后调控与增殖联系起来,突出了营养物转运蛋白在生理和病理生长中的重要性。在这里,我们回顾了最近的工作,这些工作强调了营养物转运蛋白在细胞生长和增殖中的关键作用,讨论了协调不同转运蛋白表达的翻译后机制,并考虑了在癌症和其他以不适当细胞分裂为特征的疾病中靶向这些蛋白的治疗潜力。